Results 171 to 180 of about 606,763 (357)

Microneedles at the Forefront of Next Generation Theranostics

open access: yesAdvanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang   +8 more
wiley   +1 more source

Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease

open access: yesNeurobiology of Disease, 2020
Background: Continuous compensation of dopamine represents an ideal symptomatic treatment for Parkinson's disease (PD). The feasibility in intracerebroventricular administration (i.c.v.) of dopamine previously failed because of unresolved dopamine ...
Caroline Moreau   +19 more
doaj  

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

open access: yesAdvanced Science, EarlyView.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li   +16 more
wiley   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

open access: yesAdvanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang   +4 more
wiley   +1 more source

Traumatic Aorticopulmonary Fistula Complicated By Postoperative Low Cardiac Output Treated With Dopamine

open access: green, 1967
PANACIOTIS N. SYMBAS   +5 more
openalex   +2 more sources

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

open access: yesAdvanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi   +10 more
wiley   +1 more source

Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs [PDF]

open access: green, 1974
Yvonne C. Clement‐Cormier   +3 more
openalex   +1 more source

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