Results 191 to 200 of about 563,934 (275)

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Dopamine-Mediated Analog Control of Electrochromic Reactions Through Organic Electrochemical Transistor. [PDF]

Small Sci
D'Altri G, Mariani F, Bonafè F, Decataldo F, Tessarolo M, Fraboni B, Scavetta E, Gualandi I.   +7 more
europepmc   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
wiley   +1 more source

Queen Loss Remodels Brain Dopamine and Hormonal Pathways During Worker Ovary Activation in <i>Apis mellifera</i>. [PDF]

Insects
Zhao M, Wu J, Kang W, Wei Q, Xu S, Guo H, Han B.   +6 more
europepmc   +1 more source

Recent Advances in Zirconium‐Based Metal–Organic Framework Membranes for Desalination

Advanced Science, EarlyView.
Zirconium‐based metal–organic framework membranes with tunable pore architectures, defect chemistry, and surface functionalities for Desalination are systematically reviewed. Their fabrication strategies, desalination performance across pressure‐driven, forward osmosis, and pervaporation processes, and structure–property–performance relationships are ...
Mao Fu, Hai‐Tian Xia, You Wu, Sen Li, Ying Liu, Ya‐Li Liu, Shi‐Qiang Wang, Yingchao Dong   +7 more
wiley   +1 more source

Miniaturisation of a laser-scribed graphene electrode enables analyte detection at ultra-low concentrations. [PDF]

RSC Adv
Prusty S, Upadhye S, Nayak P.
europepmc   +1 more source

Giant Conductivity Modulation and Chemical Neuromodulation via Proton‐Electron Coupling in a Hydrogen‐Bonded Coordination Polymer

Advanced Science, EarlyView.
A “de‐doping” strategy positions mixed protonic–electronic conductors (MPECs) as adaptive neuromorphic platforms with dynamically tunable transport. Co‐BAND achieves giant conductivity modulation (>106) and chemically tunable synaptic plasticity. Analogous to biological neuromodulation, solvent vapors dynamically reprogram the device's learning rules ...
Kwangmin Park, Jumin Park, Huiyeong Ju, Nasim Arafat, Byoung Gwan Lee, Joohee Oh, Eejin Jang, Hyunseob Lim, Seok Min Yoon, Dae‐Woon Lim, Intek Song   +10 more
wiley   +1 more source

The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats. [PDF]

Addict Biol
Loftén A, Danielsson K, Adermark L, Söderpalm B, Ericson M.   +4 more
europepmc   +1 more source

All Organic Fully Integrated Neuromorphic Crossbar Array

Advanced Electronic Materials, EarlyView.
In this work, the first fully integrated crossbar array of electrochemical random‐access memory (ECRAM) that is composed entirely of organic materials is represented. This array can perform inference and in situ parallel training and is capable of classifying linearly separable 2D and 3D classification tasks with high accuracy.
Setareh Kazemzadeh, Tim Stevens, Yoeri van de Burgt   +2 more
wiley   +1 more source

Mixed exposure to lead, methylmercury, and cadmium aggravates spatial memory deficits via dopamine signaling pathways in the mouse hippocampus. [PDF]

Front Public Health
Kim H, Lee D, Pyatha S, Kim K.
europepmc   +1 more source