Results 181 to 190 of about 344,927 (283)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, EarlyView.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum. [PDF]

Elife
Ejdrup A, Dreyer JK, Lycas MD, Jørgensen SH, Robbins TW, Dalley J, Herborg F, Gether U.   +7 more
europepmc   +1 more source

Reviewer #1 (Public review): Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism

Cecilia Tubert, Rodrigo M Paz, Agostina M Stahl, Lorena Rela, Mario G Murer   +4 more
openalex   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Rapid photocontrollable dopamine polymerization for instant adaptive wet adhesion. [PDF]

Nat Commun
Lu Z, Bai S, Lu H, Zhu Z, Yu J, Wang Q, Zhang P, Qian L, Zheng Z, Yu Y.   +9 more
europepmc   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Spatiotemporal Dynamics of Polyphenolic Compounds in <i>Musa</i> spp. during Ripening Revealed by Mass Spectrometry Imaging. [PDF]

J Agric Food Chem
Shinoda H, Ishimoto S, Fukusaki E, Shimma S.   +3 more
europepmc   +1 more source

Correction to: Acute phenylalanine/tyrosine depletion of phasic dopamine in the rat brain

Tatiana A. Shnitko, Sarah Taylor, Sierra J. Stringfield, Shannon L. Zandy, Roberto U. Cofresí, James M. Doherty, William B. Lynch, Charlotte A. Boettiger, Rueben A. Gonzales, Donita L. Robinson   +9 more
openalex   +1 more source

Nanozymes for Energy and Environmental Sustainability

Advanced Science, EarlyView.
At present, the widely used nanozymes are oxidoreductase and hydrolase, which have proved to have great application prospects in energy and environment. ABSTRACT Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability.
Xiaoqi Li, Jinxing Chen, Shaojun Dong
wiley   +1 more source