Results 181 to 190 of about 606,763 (357)

Temporal-Difference Learning Using Distributed Error Signals [PDF]

arXiv
A computational problem in biological reward-based learning is how credit assignment is performed in the nucleus accumbens (NAc). Much research suggests that NAc dopamine encodes temporal-difference (TD) errors for learning value predictions. However, dopamine is synchronously distributed in regionally homogeneous concentrations, which does not support
arxiv  

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Inhibition of Dopamine β-Hydroxylase by 5-Alkylpicolinic Acid and Their Hypotensive Effects

, 1969
Hiroyuki Suda, TOMIO TAKEUCHI, Toshiharu Nagatsu, MEIKI MATSUZAKI, Ikuo Matsumoto, HAMAO UMEZAWA   +5 more
openalex   +2 more sources

Plasma adrenaline, noradrenaline and dopamine in man and different animal species [PDF]

, 1978
H. U. Bühler, M. Da Prada, W. Haefely, Giovanni B. Picotti   +3 more
openalex   +1 more source

Balancing H* Adsorption/Desorption by Localized 4f Orbital Electrons of Lanthanide Dopants in Carbon‐Encapsulated MoP for Boosted Hydrogen Evolution

Advanced Science, EarlyView.
The Pt‐like electronic structure and fast electron transfer channels induced by Ln dopant (Ln: La, Ce, Sm, Gd, and Yb) demonstrate enhanced contribution for hydrogen evolution reaction. Abstract MoP is one of the most efficient catalysts for hydrogen evolution reaction (HER).
Jiancheng Li, Juanli Zhao, Yanning Zhang, Yuchen Liu, Maoyuan Li, Riyue Ge, Wenxian Li, Bin Liu   +7 more
wiley   +1 more source

GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABAA receptors

Cell Reports
Summary: Striatal dopamine axons co-release dopamine and gamma-aminobutyric acid (GABA), using GABA provided by uptake via GABA transporter-1 (GAT1). Functions of GABA co-release are poorly understood.
Jyoti C. Patel, Ang D. Sherpa, Riccardo Melani, Paul Witkovsky, Madeline R. Wiseman, Brian O’Neill, Chiye Aoki, Nicolas X. Tritsch, Margaret E. Rice   +8 more
doaj  

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

Advanced Science, EarlyView.
This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei   +11 more
wiley   +1 more source

Concomitant changes in formaldehyde‐induced fluorescence of dopamine interneurones and in slow inhibitory post‐synaptic potentials of the rabbit superior cervical ganglion, induced by stimulation of the preganglionic nerve or by a muscarinic agent [PDF]

, 1974
Benjamin Libet, Ch. Owman
openalex   +1 more source

Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles

Advanced Science, EarlyView.
This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen, Gaoxiang Xu, Runpu Shen, Jianzhong Xu, Congcong Lu, Xin Li, Qi Feng, Qing Li   +7 more
wiley   +1 more source