Results 11 to 20 of about 807,462 (376)
Annual Review of Psychology, 2020 Addiction is commonly identified with habitual nonmedical self-administration of drugs. It is usually defined by characteristics of intoxication or by characteristics of withdrawal symptoms.
R. Wise, Mykel A. Robble
semanticscholar +3 more sources
KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant [PDF]
, 2015 Dopamine D-4 Receptor Polymorphism : The dopamine D-4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit ...
Lintermans, Béatrice +3 more
core +14 more sources
Conformation of dopamine at the dopamine receptor. [PDF]
Proceedings of the National Academy of Sciences, 1978 Tritiated dopamine was used to label the dopamine receptor in membranes isolated from the rat corpus striatum. Scatchard analysis of displacement of [3H]dopamine by nonradioactive dopamine indicated the presence of two binding sites. The similarities in affinity, capacity, and drug specificity of the high-affinity site in the striatal membranes from ...
Duane D. Miller +3 more
openaire +3 more sources
Electrochemical Aptasensor for Detection of Dopamine [PDF]
, 2020 This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer
Abu-Ali, Hisham +4 more
core +1 more source
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
World Psychiatry, 2020 Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both have been proposed to contribute significantly to the pathophysiology of schizophrenia.
R. McCutcheon, J. Krystal, O. Howes
semanticscholar +1 more source
Psychology Review, 2002 The authors present a unified account of 2 neural systems concerned with the development and expression of adaptive behaviors: a mesencephalic dopamine system for reinforcement learning and a "generic" error-processing system associated with the anterior
Clay B. Holroyd, M. Coles
semanticscholar +1 more source
Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake [PDF]
, 2017 Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to
Baker, David A. +9 more
core +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1988 The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by ...
G. Dichiara, A. Imperato
semanticscholar +1 more source
Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. [PDF]
, 2016 BackgroundCigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence.
London, Edythe D +2 more
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PLoS ONE, 2013 Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals.
Seiji Hayashizaki +8 more
doaj +1 more source