Results 201 to 210 of about 835,082 (382)

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

Nature Reviews Neuroscience, 2016
A. Grace
semanticscholar   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

The dynamics of synaptic dopamine clearance: relevance to alcohol use disorder

Impulse: The Premier Undergraduate Neuroscience Journal
Alcohol misuse is a leading cause of preventable death, yet the neurochemical changes governing its addictive properties remain elusive. Ethanol, the psychoactive component of alcoholic beverages, interacts with many neurotransmitter systems, including ...
Karina Piotrowska, Elaine Fitches
doaj  

Novelty Influences Dopamine Responses to Conditioned and Unconditioned Aversive Stimuli over Extended Temporal Windows. [PDF]

eNeuro
Kutlu MG, Cajigas Gabriel SA, Tat J, Zachry JE, Calipari ES.   +4 more
europepmc   +1 more source

Intracranial subsecond dopamine measurements during a “sure bet or gamble” decision-making task in patients with alcohol use disorder suggest diminished dopaminergic signals about relief

, 2023
Brittany Liebenow, Angela J. Jiang, Emily K. DiMarco, Thomas G. Wilson, Mustafa Siddiqui, Ihtsham Haq, Adrian W. Laxton, Stephen B. Tatter, Kenneth T. Kishida   +8 more
openalex   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Caste- and age-specific venom composition of biogenic amines and the influence of diet in honey bees. [PDF]

PLoS One
Hamano M, Niki K, Imamura K, Sasaki K.
europepmc   +1 more source

Dopamine and dobutamine [PDF]

BMJ, 1978
openaire   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source