Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation [PDF]
, 2015 In rodent models of Parkinsons disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia.
Aboud, O +6 more
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Neurobiology of Disease, 2015 The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol
S.T. Masoud +16 more
doaj +1 more source
Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]
, 2014 Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
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eLife, 2017 Dopamine neurons are thought to encode novelty in addition to reward prediction error (the discrepancy between actual and predicted values). In this study, we compared dopamine activity across the striatum using fiber fluorometry in mice.
William Menegas +3 more
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Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA. [PDF]
PLoS ONE, 2012 Dopamine D(2) receptor partial agonist antipsychotic drugs can modulate dopaminergic neurotransmission as functional agonists or functional antagonists.
Hiroshi Ito +8 more
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Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release
eLife, 2020 Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow ...
Aditi Banerjee +4 more
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M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. [PDF]
PLoS ONE, 2011 Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so mainly by inhibiting GABA neurons near the ventral tegmental area (VTA), in turn leading to a disinhibition of dopamine neurons.
Stephan Steidl +3 more
doaj +1 more source
BMJ, 1997 Renal failure often manifests as oliguria. Many therefore view oliguria as a sinister development that should be prevented or treated in the hope of avoiding renal failure. However, oliguria can be a normal physiological response and, in itself, is a poor predictor of acute renal failure.1 2 Nevertheless, dopamine infusions have gained popularity over ...
David W Noble, Brian H Cuthbertson
openaire +3 more sources
Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice [PDF]
, 2008 Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not
Atkins +47 more
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Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System [PDF]
The Journal of Neuroscience, 2019 The relationship between neuronal impulse activity and neurotransmitter release remains elusive. This issue is especially poorly understood in the neuroendocrine system, with its particular demands on periodically voluminous release of neurohormones at the interface of axon terminals and vasculature.
Stefanos Stagkourakis +4 more
openaire +5 more sources