Results 21 to 30 of about 506,450 (362)
Dopamine Release Dynamics in the Tuberoinfundibular Dopamine System [PDF]
The Journal of Neuroscience, 2019 The relationship between neuronal impulse activity and neurotransmitter release remains elusive. This issue is especially poorly understood in the neuroendocrine system, with its particular demands on periodically voluminous release of neurohormones at the interface of axon terminals and vasculature.
Stefanos Stagkourakis +4 more
openaire +5 more sources
Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release
eLife, 2020 Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow ...
Aditi Banerjee +4 more
doaj +1 more source
Mâ‚… muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. [PDF]
PLoS ONE, 2011 Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so mainly by inhibiting GABA neurons near the ventral tegmental area (VTA), in turn leading to a disinhibition of dopamine neurons.
Stephan Steidl +3 more
doaj +1 more source
BMJ, 1997 Renal failure often manifests as oliguria. Many therefore view oliguria as a sinister development that should be prevented or treated in the hope of avoiding renal failure. However, oliguria can be a normal physiological response and, in itself, is a poor predictor of acute renal failure.1 2 Nevertheless, dopamine infusions have gained popularity over ...
David W Noble, Brian H Cuthbertson
openaire +3 more sources
Dissociable dopamine dynamics for learning and motivation.
Nature, 2019 The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is critical for motivation to work for rewards and reward-driven learning. How dopamine supports both functions is unclear.
Ali Mohebi +8 more
semanticscholar +1 more source
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
Science, 2018 Imaging dopamine release in the brain Neuromodulator release alters the function of target circuits in poorly known ways. An essential step to address this knowledge gap is to measure the dynamics of neuromodulatory signals while simultaneously ...
T. Patriarchi +16 more
semanticscholar +1 more source
Specialized coding of sensory, motor, and cognitive variables in VTA dopamine neurons
Nature, 2019 There is increased appreciation that dopamine neurons in the midbrain respond not only to reward1 and reward-predicting cues1,2, but also to other variables such as the distance to reward3, movements4–9 and behavioural choices10,11. An important question
B. Engelhard +10 more
semanticscholar +1 more source
Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. [PDF]
PLoS ONE, 2014 Adolescent males have an increased risk of developing schizophrenia, implicating testosterone in the precipitation of dopamine-related psychopathology.
Tertia D Purves-Tyson +5 more
doaj +1 more source
The dopamine hypothesis of schizophrenia: version III--the final common pathway.
Schizophrenia bulletin, 2009 The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of schizophrenia (version I), but it was subsequently reconceptualized to specify ...
O. Howes, S. Kapur
semanticscholar +1 more source
Nature Reviews Neuroscience, 2019 Midbrain dopamine signals are widely thought to report reward prediction errors that drive learning in the basal ganglia. However, dopamine has also been implicated in various probabilistic computations, such as encoding uncertainty and controlling exploration.
S. Gershman, N. Uchida
semanticscholar +5 more sources