Results 21 to 30 of about 259,710 (99)

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

eLife, 2017
LRRK2 mutations produce end-stage Parkinson’s disease (PD) with reduced nigrostriatal dopamine, whereas, asymptomatic carriers have increased dopamine turnover and altered brain connectivity.
Mattia Volta, Dayne A Beccano-Kelly, Sarah A Paschall, Stefano Cataldi, Sarah E MacIsaac, Naila Kuhlmann, Chelsie A Kadgien, Igor Tatarnikov, Jesse Fox, Jaskaran Khinda, Emma Mitchell, Sabrina Bergeron, Heather Melrose, Matthew J Farrer, Austen J Milnerwood   +14 more
doaj   +1 more source

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

Neurobiology of Disease, 2015
Dopamine function is disturbed in Parkinson's disease (PD), but whether and how release of dopamine from surviving neurons is altered has long been debated.
Katie A. Jennings, Nicola J. Platt, Stephanie J. Cragg   +2 more
doaj   +1 more source

Functional characterization of dopamine transporter in vivo using Drosophila melanogaster behavioral analysis.

Frontiers in Behavioral Neuroscience, 2014
Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno, Taro eUeno, Kazuhiko eKume, Kazuhiko eKume   +3 more
doaj   +1 more source

Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. [PDF]

PLoS ONE, 2014
Adolescent males have an increased risk of developing schizophrenia, implicating testosterone in the precipitation of dopamine-related psychopathology.
Tertia D Purves-Tyson, Samantha J Owens, Kay L Double, Reena Desai, David J Handelsman, Cynthia Shannon Weickert   +5 more
doaj   +1 more source

Mesolimbic dopamine transients in motivated behaviors: focus on maternal behavior

Frontiers in Psychiatry, 2011
Phasic activity of the mesolimbic dopamine pathway – burst firing of dopamine neurons and the resulting dopamine release events at striatal targets – have been associated with a variety of motivational events, such as novelty, salient stimuli, social ...
Donita L Robinson, Donita L Robinson, Donita L Robinson, Dawnya L Zitzman, Sarah K Williams, Sarah K Williams   +5 more
doaj   +1 more source

Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

Frontiers in Synaptic Neuroscience, 2018
This perspective article provides observations supporting the view that nigro-striatal dopamine neurons and meso-limbic dopamine neurons mainly communicate through short distance volume transmission in the um range with dopamine diffusing into ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Miguel Perez De La Mora, Paul Manger, Manuel Narváez, Sarah Beggiato, Minerva Crespo-Ramírez, Gemma Navarro, Karolina Wydra, Zaida Díaz-Cabiale, Alicia Rivera, Luca Ferraro, Sergio Tanganelli, Małgorzata Filip, Rafael Franco, Rafael Franco, Kjell Fuxe   +17 more
doaj   +1 more source

High concentration of dopamine treatment may induce acceleration of human sperm motility

Reproductive Medicine and Biology, 2022
Purpose In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region.
Hiroki Kanno, Shouhei Kurata, Yuuki Hiradate, Kenshiro Hara, Hiroaki Yoshida, Kentaro Tanemura   +5 more
doaj   +1 more source

Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insulin Signaling and Metabolic Function

Frontiers in Pharmacology, 2021
Dopamine is a key regulator of glucose metabolism in the central nervous system. However, dopamine is also present in the periphery and may have direct effects on insulin-sensitive tissues.
Gabriela Tavares, Gabriela Tavares, Gabriela Tavares, Gabriela Tavares, Fatima. O. Martins, Bernardete. F. Melo, Paulo Matafome, Paulo Matafome, Paulo Matafome, Paulo Matafome, Silvia. V. Conde   +10 more
doaj   +1 more source

D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons. [PDF]

PLoS ONE, 2012
Dopamine signaling modulates voluntary movement and reward-driven behaviors by acting through G protein-coupled receptors in striatal neurons, and defects in dopamine signaling underlie Parkinson's disease and drug addiction.
Khursheed A Wani, Mary Catanese, Robyn Normantowicz, Muriel Herd, Kathryn N Maher, Daniel L Chase   +5 more
doaj   +1 more source

Regulatory mechanisms of dopamine metabolism in a marine Meyerozyma guilliermondii GXDK6 under NaCl stress as revealed by integrative multi-omics analysis

Synthetic and Systems Biotechnology
Dopamine can be used to treat depression, myocardial infarction, and other diseases. However, few reports are available on the de novo microbial synthesis of dopamine from low-cost substrate. In this study, integrated omics technology was used to explore
Huijie Sun, Huashan Bai, Yonghong Hu, Sheng He, Ruihang Wei, Duotao Meng, Qiong Jiang, Hongping Pan, Peihong Shen, Qian Ou, Chengjian Jiang   +10 more
doaj   +1 more source