Results 11 to 20 of about 359,850 (311)

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

Neurobiology of Disease, 2015
The dopamine transporter is a key protein responsible for regulating dopamine homeostasis. Its function is to transport dopamine from the extracellular space into the presynaptic neuron. Studies have suggested that accumulation of dopamine in the cytosol
S.T. Masoud, L.M. Vecchio, Y. Bergeron, M.M. Hossain, L.T. Nguyen, M.K. Bermejo, B. Kile, T.D. Sotnikova, W.B. Siesser, R.R. Gainetdinov, R.M. Wightman, M.G. Caron, J.R. Richardson, G.W. Miller, A.J. Ramsey, M. Cyr, A. Salahpour   +16 more
doaj   +1 more source

Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA. [PDF]

PLoS ONE, 2012
Dopamine D(2) receptor partial agonist antipsychotic drugs can modulate dopaminergic neurotransmission as functional agonists or functional antagonists.
Hiroshi Ito, Harumasa Takano, Ryosuke Arakawa, Hidehiko Takahashi, Fumitoshi Kodaka, Keisuke Takahata, Tsuyoshi Nogami, Masayuki Suzuki, Tetsuya Suhara   +8 more
doaj   +1 more source

Stimulus representation and the timing of reward-prediction errors in models of the dopamine system [PDF]

, 2008
The phasic firing of dopamine neurons has been theorized to encode a reward-prediction error as formalized by the temporal-difference (TD) algorithm in reinforcement learning.
Sutton, Richard S., Kehoe, E. James, Ludvig, Elliot Andrew   +2 more
core   +1 more source

Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice

eLife, 2017
Dopamine neurons are thought to encode novelty in addition to reward prediction error (the discrepancy between actual and predicted values). In this study, we compared dopamine activity across the striatum using fiber fluorometry in mice.
William Menegas, Benedicte M Babayan, Naoshige Uchida, Mitsuko Watabe-Uchida   +3 more
doaj   +1 more source

M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. [PDF]

PLoS ONE, 2011
Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so mainly by inhibiting GABA neurons near the ventral tegmental area (VTA), in turn leading to a disinhibition of dopamine neurons.
Stephan Steidl, Anthony D Miller, Charles D Blaha, John S Yeomans   +3 more
doaj   +1 more source

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation [PDF]

, 2012
BACKGROUND: Dopamine plays an important role in orienting, response anticipation and movement evaluation. Thus, we examined the influence of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O ...
Laucht, Manfred (Prof. Dr.), Rellum Thomas, Thomas Rellum, Resch, Franz, Stephan Bender, Brandeis, Daniel, Banaschewski, Tobias, Laucht Manfred, Bender, Stephan, Rietschel, Marcella, Jennen-Steinmetz, Christine, Freitag, Christine M., Treutlein, Jens, Jens Treutlein, Rellum, Thomas, Daniel Brandeis, Brandeis Daniel, Tobias Banaschewski, Jennen-Steinmetz Christine, Christine Freitag, Bender Stephan, Banaschewski Tobias, Manfred Laucht, Freitag, Christine, Franz Resch, Rietschel Marcella, Marcella Rietschel, Resch Franz, Christine Jennen-Steinmetz, Laucht, Manfred, Treutlein Jens, Freitag Christine   +31 more
core   +1 more source

Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

eLife, 2020
Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow ...
Aditi Banerjee, Jinoh Lee, Paulina Nemcova, Changliang Liu, Pascal S Kaeser   +4 more
doaj   +1 more source

Conformation of dopamine at the dopamine receptor. [PDF]

Proceedings of the National Academy of Sciences, 1978
Tritiated dopamine was used to label the dopamine receptor in membranes isolated from the rat corpus striatum. Scatchard analysis of displacement of [3H]dopamine by nonradioactive dopamine indicated the presence of two binding sites. The similarities in affinity, capacity, and drug specificity of the high-affinity site in the striatal membranes from ...
H L, Komiskey, J F, Bossart, D D, Miller, P N, Patil   +3 more
openaire   +2 more sources

Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors

Journal of Pharmacological Sciences, 2012
Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson’s disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they interact with
Hiroko Ikeda, Junzo Kamei, Noriaki Koshikawa, Alexander R. Cools   +3 more
doaj   +1 more source

Dopamine restores reward prediction errors in old age [PDF]

, 2013
Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value ...
Dayan, P., Dolan, Raymond J, Dayan, P, Dolan, R., Huys, Q., Guitart-Masip, M. ; https://orcid.org/, Düzel, E., Rumana Chowdhury, Chowdhury, R., Christian Lambert, Emrah Düzel, Duezel, Emrah, Guitart-Masip, M., Dolan, Raymond J., Lambert, C., Lambert, C, Chowdhury, Rumana, Chowdhury, R, Guitart-Masip, Marc,, Guitart-Masip, Marc, Dolan, RJ, Marc Guitart-masip, Düzel, E, Dolan, R. ; https://orcid.org/, Raymond J Dolan, Peter Dayan, Dayan, Peter, Guitart-Masip, M, Düzel, Emrah, Huys, Q, Lambert, Christian, Quentin Huys, Huys, Quentin   +32 more
core   +1 more source