Results 41 to 50 of about 506,450 (362)

Functional characterization of dopamine transporter in vivo using Drosophila melanogaster behavioral analysis.

Frontiers in Behavioral Neuroscience, 2014
Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno, Taro eUeno, Kazuhiko eKume, Kazuhiko eKume   +3 more
doaj   +1 more source

D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons. [PDF]

PLoS ONE, 2012
Dopamine signaling modulates voluntary movement and reward-driven behaviors by acting through G protein-coupled receptors in striatal neurons, and defects in dopamine signaling underlie Parkinson's disease and drug addiction.
Khursheed A Wani, Mary Catanese, Robyn Normantowicz, Muriel Herd, Kathryn N Maher, Daniel L Chase   +5 more
doaj   +1 more source

Phasic dopamine release identification using ensemble of AlexNet [PDF]

arXiv, 2020
Dopamine (DA) is an organic chemical that influences several parts of behaviour and physical functions. Fast-scan cyclic voltammetry (FSCV) is a technique used for in vivo phasic dopamine release measurements. The analysis of such measurements, though, requires notable effort.
arxiv  

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Science, 2017
Human-derived neurons provide the answers Pathways involved in energy metabolism and removal of cellular debris by lysosomes play an important role in protecting our brain from degeneration in Parkinson's disease. Burbulla et al.
Lena F. Burbulla, Lena F. Burbulla, Pingping Song, Joseph R. Mazzulli, Joseph R. Mazzulli, E. Zampese, Y. Wong, S. Jeon, David P. Santos, Judith Blanz, Carolin D. Obermaier, Carolin D. Obermaier, Chelsee Strojny, J. Savas, E. Kiskinis, X. Zhuang, Rejko Krüger, Rejko Krüger, Rejko Krüger, D. Surmeier, D. Krainc, D. Krainc   +21 more
semanticscholar   +1 more source

Dopamine Receptor

Definitions, 2020
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
Raymond Turco
semanticscholar   +1 more source

Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro, Neetha Paul Eduthan, Mellad M. Khoshnood, Saba Jafarpour, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Lilia Kazerooni, Eleanor Britton, Hannah R. Lyford, Matthew D. Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa   +12 more
wiley   +1 more source

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

eLife, 2017
LRRK2 mutations produce end-stage Parkinson’s disease (PD) with reduced nigrostriatal dopamine, whereas, asymptomatic carriers have increased dopamine turnover and altered brain connectivity.
Mattia Volta, Dayne A Beccano-Kelly, Sarah A Paschall, Stefano Cataldi, Sarah E MacIsaac, Naila Kuhlmann, Chelsie A Kadgien, Igor Tatarnikov, Jesse Fox, Jaskaran Khinda, Emma Mitchell, Sabrina Bergeron, Heather Melrose, Matthew J Farrer, Austen J Milnerwood   +14 more
doaj   +1 more source

Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons

Science, 2003
Uncertainty is critical in the measure of information and in assessing the accuracy of predictions. It is determined by probability P, being maximal at P = 0.5 and decreasing at higher and lower probabilities.
C. Fiorillo, P. Tobler, W. Schultz
semanticscholar   +1 more source

Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Visual disability in Parkinson's disease (PD) is not fully explained by retinal neurodegeneration. We aimed to delineate the brain substrate of visual dysfunction in PD and its association with retinal thickness. Methods Forty‐two PD patients and 29 controls underwent 3‐Tesla MRI, retinal spectral‐domain optical coherence tomography,
Asier Erramuzpe, Ane Murueta‐Goyena, Antonio Jimenez‐Marin, Marian Acera, Sara Teijeira‐Portas, Rocío Del Pino, Tamara Fernández‐Valle, Ibai Diez, Unai Sainz‐Lugarezaresti, Naroa Ibarretxe‐Bilbao, Unai Ayala, Maitane Barrenechea, Alberto Cabrera‐Zubizarreta, Jesús Cortés, Juan Carlos Gómez‐Esteban, Iñigo Gabilondo   +15 more
wiley   +1 more source

Mesolimbic dopamine transients in motivated behaviors: focus on maternal behavior

Frontiers in Psychiatry, 2011
Phasic activity of the mesolimbic dopamine pathway – burst firing of dopamine neurons and the resulting dopamine release events at striatal targets – have been associated with a variety of motivational events, such as novelty, salient stimuli, social ...
Donita L Robinson, Donita L Robinson, Donita L Robinson, Dawnya L Zitzman, Sarah K Williams, Sarah K Williams   +5 more
doaj   +1 more source