ヘキサナール刺激でドーパミンを放出した PC12 細胞のドーパミンの再蓄積作用 [PDF]
すべての食品に匂い(香り)がある.食品に含まれる匂い(香り)物質は,食品中の栄養素と同様に体内に取り込まれ,生理作用を示すと考えている. ヘキサナールは炭素数6 の直鎖アルデヒドであり,植物特有の新鮮な香りを構成している物質の1 つである. これまでに,私たちは,ヘキサナールがラット脳線条体切片及びラット副腎褐色細胞腫(PC12)細胞からのドーパミン放出を促進することを報告している. ドーパミンを放出した細胞は,次の刺激に応答するために,細胞内にドーパミンを再蓄積する必要がある. 本研究では ...
Kobayashi, Yoko, 小林, 葉子
core
Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis [PDF]
Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified.
arxiv +1 more source
Neuronal and psychological underpinnings of pathological gambling [PDF]
Like in the case of drugs, gambling hijacks reward circuits in a brain which is not prepared to receive such intense stimulation. Dopamine is normally released in response to reward and uncertainty in order to allow animals to stay alive in their ...
Anselme+18 more
core +3 more sources
Midbrain dopamine signals are widely thought to report reward prediction errors that drive learning in the basal ganglia. However, dopamine has also been implicated in various probabilistic computations, such as encoding uncertainty and controlling exploration.
Samuel J. Gershman, Naoshige Uchida
openaire +4 more sources
Melanin Made by Dopamine Oxidation: Thin Films and Interactions with Polyelectrolyte Multilayers [PDF]
The spontaneous oxidation of dopamine in slightly alkaline solutions was investigated on the basis of the work of Lee and others [Science, 318:426-430, 2007], and the reaction product was identified as dopamine-melanin. The ability of melanin to covalently bind amine functional groups was confirmed by quantification of the corresponding binding sites ...
arxiv
Inclusion of Enclosed Hydration Effects in the Binding Free Energy Estimation of Dopamine D3 Receptor Complexes [PDF]
Confined hydration and conformational flexibility are some of the challenges encountered for the rational design of selective antagonists of G-protein coupled receptors. We present a set of C3-substituted (-)-stepholidine derivatives as potent binders of the dopamine D3 receptor.
arxiv +1 more source
Prenatal Nicotine Exposure as a Teratogen in Neurological Pathways [PDF]
Attention-deficit/hyperactivity disorder (ADHD) is the most heritable and commonly diagnosed childhood psychiatric disorder with 4% of all children being diagnosed with this disorder.
Grover, Monica
core +1 more source
Dopamine-modulated dynamic cell assemblies generated by the GABAergic striatal microcircuit [PDF]
The striatum, the principal input structure of the basal ganglia, is crucial to both motor control and learning. It receives convergent input from all over the neocortex, hippocampal formation, amygdala and thalamus, and is the primary recipient of ...
Alexander+92 more
core +1 more source
Electronic schematic for bio-plausible dopamine neuromodulation of eSTDP and iSTDP [PDF]
In this technical report we present novel results of the dopamine bio-plausible neuromodulation excitatory (eSTDP) and inhibitory (iSTDP) learning. We present the principal schematic for the neuromodulation of D1 and D2 receptors of dopamine, wiring schematic for both cases as well as the simulatory experiments results done in LTSpice.
arxiv
Interactions of dopamine and dopamine hydrochloride with ethanol [PDF]
Abstract Cyclic voltammetry (CV), density functional theory (DFT) calculations, and atoms in molecules (AIM) analyses were performed to investigate the hydrogen bonding in dopamine-ethanol and dopamine hydrochloride-ethanol mixtures. CV results show that the anodic/cathodic peak potential of dopamine hydrochloride in ethanol is influenced by the ...
Huiting Ma+6 more
openaire +2 more sources