Results 41 to 50 of about 835,082 (382)

Heterogeneity of dopamine release sites in health and degeneration

Neurobiology of Disease, 2020
Despite comprising only ~ 0.001% of all neurons in the human brain, ventral midbrain dopamine neurons exert a profound influence on human behavior and cognition.
Joseph J. Lebowitz, Habibeh Khoshbouei
doaj   +1 more source

Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology [PDF]

, 2008
Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson’s disease (PD), linked recently to proteasomal dysfunction.
Beck, KE, Billett, EE, Caneda-Ferrón, B, Costa, T, De, Girolamo, Layfield, R   +5 more
core   +1 more source

Putting Desire on a Budget: Dopamine and Energy Expenditure, Reconciling Reward and Resources

Frontiers in Integrative Neuroscience, 2012
Accumulating evidence indicates integration of dopamine function with metabolic signals, highlighting a potential role for dopamine in energy balance, frequently construed as modulating reward in response to homeostatic state.
Jeff A Beeler, Cristianne R.M. Frazier, Xiaoxi eZhuang, Xiaoxi eZhuang   +3 more
doaj   +1 more source

Neuronal and psychological underpinnings of pathological gambling [PDF]

, 2014
Like in the case of drugs, gambling hijacks reward circuits in a brain which is not prepared to receive such intense stimulation. Dopamine is normally released in response to reward and uncertainty in order to allow animals to stay alive in their ...
Anselme, Bryan F. Singer, Clark, Goudriaan, Kalkhoven, Lawrence, Li, Linnet, Mike J. F. Robinson, Paglieri, Patrick Anselme, Paul Vezina, Porchet, Potenza, Singer, Tedford, van den Bos, Zack, Zack   +18 more
core   +3 more sources

The impact of a parkinsonian lesion on dynamic striatal dopamine transmission depends on nicotinic receptor activation

Neurobiology of Disease, 2015
Dopamine function is disturbed in Parkinson's disease (PD), but whether and how release of dopamine from surviving neurons is altered has long been debated.
Katie A. Jennings, Nicola J. Platt, Stephanie J. Cragg   +2 more
doaj   +1 more source

GABAergic-like dopamine synapses in the brain

Cell Reports, 2023
Summary: Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine synapses causes various psychiatric and neurological disorders.
Hyun-Jin Kim, Byungjae Hwang, Maria Reva, Jieun Lee, Byeong Eun Lee, Youngeun Lee, Eun Jeong Cho, Minseok Jeong, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Jung-Hoon Park, Jae-Ick Kim   +12 more
doaj   +1 more source

Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. [PDF]

, 2015
Dysfunction of the mesocorticolimbic system has a critical role in clinical features of addiction. Despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in ...
Dean, AC, Kohno, M, London, ED, Mandelkern, MA, Morales, AM, Robertson, CL   +5 more
core   +4 more sources

Functional characterization of dopamine transporter in vivo using Drosophila melanogaster behavioral analysis.

Frontiers in Behavioral Neuroscience, 2014
Dopamine mediates diverse functions such as motivation, reward, attention, learning/memory and sleep/arousal. Recent studies using model organisms including the fruit fly, have elucidated various physiological functions of dopamine, and identified ...
Taro eUeno, Taro eUeno, Kazuhiko eKume, Kazuhiko eKume   +3 more
doaj   +1 more source

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]

, 2014
Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
A Garcia-Espana, A Moszczynska, A Priyadarshi, Alexander Holmes, Anton Gartner, AT Allen, B Giros, C Boucheix, C Boucheix, C Boucheix, C Klein, C Missale, CD Dunn, CH Lai, D Vallone, DB Calne, DL Chase, E Rubinstein, E Rubinstein, EA Bolan, ER Sawin, ES Calipari, FJ Lee, FJ Lee, GC Cotzias, GR Uhl, H Maharaj, H Moribe, H Moribe, HP Rang, J Bove, J Sulston, JE Galvin, JG White, JM Beaulieu, JW Langston, K Jellinger, K Strange, K Tieu, KF Tipton, Kim A. Caldwell, L Carvelli, LD Jayanthi, M Santiago, MJ Ferris, MJ LaVoie, MJ Zigmond, ML Toth, MS Szczypka, MW Davis, MY Chang, N Chen, Neda Masoudi, O Thompson, P Seeman, P Seeman, P Sokoloff, Pablo Ibanez-Cruceyra, PW McDonald, QY Zhou, R Andrew, R Nass, R Nass, RM Kostrzewa, RR Gainetdinov, S Brenner, S Cao, S Charrin, S Fahn, S Fahn, S Thaminy, Sarah-Lena Offenburger, TN Chase, W Birkmayer, WA Cass, Y Glinka   +75 more
core   +5 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source