Results 51 to 60 of about 359,850 (311)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons. [PDF]
PLoS ONE, 2012 Dopamine signaling modulates voluntary movement and reward-driven behaviors by acting through G protein-coupled receptors in striatal neurons, and defects in dopamine signaling underlie Parkinson's disease and drug addiction.
Khursheed A Wani +5 more
doaj +1 more source
Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice
, 2012 Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD.
Auburger, G +15 more
core +1 more source
Slight Truncation Changes in Iron Oxide Nanocubes Strongly Affect Their Magnetic Properties
Advanced Functional Materials, EarlyView.Subtle variations in nanoparticle morphology can lead to significant changes in functional properties. An automated shape‐fitting method captures minor differences in corner truncation between iron oxide nanocubes of similar sizes synthesized under identical conditions, revealing pronounced disparities in their magnetic and hyperthermia behavior ...
Kingsley Poon +7 more
wiley +1 more source
Annals of Medicine, 1996 The DA hypothesis of schizophrenia is one of the oldest biological hypotheses of schizophrenia with many revised versions. However, it is unlikely that any single neurotransmitter hypothesis is able to explain the biological basis of such a highly heterogenous disorder as schizophrenia in a satisfactory way.
J, Hietala, E, Syvälahti
openaire +2 more sources
In vivo imaging of dopamine and serotonin release: response to psychopharmacological challenges [PDF]
, 2005 De neurotransmitters dopamine en serotonine zijn betrokken bij vele processen waaronder de regulatie van beloningsmechanismen (dopamine) en de stemming (serotonine).
Udo de Haes, Joanna Irene, +1 more
core
Dopaminergic modulation of odor responses by local interneurons in the olfactory bulb [PDF]
, 2011 The olfactory bulb is one of the few regions in the brain where dopamine is provided locally by an intrinsic population of GABAergic interneurons but their role in processing of sensory information remains ambiguous.
Bundschuh, Sebastian Tylman
core +1 more source
Advanced Functional Materials, EarlyView.Multianalyte, real‐time monitoring of bioprinted scaffolds remains challenging. Phosphorescence‐lifetime–based, optically responsive microparticles are embedded in diverse printable hydrogels (κ‐carrageenan, GelMA, PEGDA) to form biomaterial inks that report oxygen, glucose, lactate, and temperature.
Waqas Saleem +11 more
wiley +1 more source
Synthetic and Systems BiotechnologyDopamine can be used to treat depression, myocardial infarction, and other diseases. However, few reports are available on the de novo microbial synthesis of dopamine from low-cost substrate. In this study, integrated omics technology was used to explore
Huijie Sun +10 more
doaj +1 more source
Frontiers in Psychiatry, 2011 Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc ...
Helga eHöifödt Lidö +4 more
doaj +1 more source