Results 51 to 60 of about 506,450 (362)
Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors
Communications Biology, 2022 Dopamine sensor cell lines expressing fluorescent reporters are developed. This versatile tool can record endogenous dopamine release from cultured neurons and striatal slices, determine dopamine tissue content, and detect dopamine uptake and efflux.
Carmen Klein Herenbrink +10 more
doaj +1 more source
Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the relationship of early BMI change with subsequent cognitive decline, CSF AD biomarkers alterations, and progression to dementia in patients with PD. Methods Study data were prospectively collected from the PPMI cohort. Weight/height data at enrollment and second‐year clinical visit were utilized to calculate BMI change.
Rui Zhong, Kezhong Zhang
wiley +1 more source
eLife, 2022 Repeated exposure to drugs of abuse results in an upregulation of cAMP signaling in the mesolimbic dopamine system, a molecular adaptation thought to be critically involved in the development of drug dependence.
Xiaojie Liu +10 more
doaj +1 more source
Arthritis Care &Research, Accepted Article.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co‐morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
An expanded palette of dopamine sensors for multiplex imaging in vivo
Nature Methods, 2020 Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable high-resolution imaging of dopamine dynamics in behaving animals.
T. Patriarchi +12 more
semanticscholar +1 more source
Advanced Biology, EarlyView.Coacervation driven by liquid‐liquid phase separation (LLPS) of biopolymers has garnered increasing attention in biology since this leads to the formation of membraneless organelles capable of performing essential yet largely unknown functions. This review highlights recent advances in coacervates (artificial condensates) composed of low‐molecular ...
Sayuri L. Higashi, Masato Ikeda
wiley +1 more source
Frontiers in Pharmacology, 2021 Dopamine is a key regulator of glucose metabolism in the central nervous system. However, dopamine is also present in the periphery and may have direct effects on insulin-sensitive tissues.
Gabriela Tavares +10 more
doaj +1 more source
On the Origin of Tremor in Parkinson's Disease [PDF]
(2012) PLoS ONE 7(7): e41598, 2012 The exact origin of tremor in Parkinson's disease remains unknown. We explain why the existing data converge on the basal ganglia-thalamo-cortical loop as a tremor generator and consider a conductance-based model of subthalamo-pallidal circuits embedded into a simplified representation of the basal ganglia-thalamo-cortical circuit to investigate the ...
arxiv +1 more source
Advanced Engineering Materials, EarlyView.This article provides a comprehensive overview of fundamentals and recent advances of transparent thin‐film surface acoustic wave technologies on glass substrates for monitoring and prevention/elimination of fog, ice, and frost. Fogging, icing, or frosting on optical lenses, optics/photonics, windshields, vehicle/airplane windows, and solar panel ...
Hui Ling Ong +11 more
wiley +1 more source
Dopamine: Differentially Private Federated Learning on Medical Data [PDF]
arXiv, 2021 While rich medical datasets are hosted in hospitals distributed across the world, concerns on patients' privacy is a barrier against using such data to train deep neural networks (DNNs) for medical diagnostics. We propose Dopamine, a system to train DNNs on distributed datasets, which employs federated learning (FL) with differentially-private ...
arxiv