Results 71 to 80 of about 826,720 (382)

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source

Plasma functionalized surface of commodity polymers for dopamine detection [PDF]

, 2017
We have fabricated potentially generalizable sensors based on polymeric-modified electrodes for the electrochemical detection of dopamine. Sensitive and selective sensors have been successfully obtained by applying a cold-plasma treatment during 1–2 min ...
Alemán Llansó, Carlos, Armelín Diggroc, Elaine Aparecida, Buendía Morales, Jorge Juan, Castedo Rodríguez, Alejandra, Fabregat Jové, Georgina, Llorca Piqué, Jordi, Osorio Madrigal, Joaquin   +6 more
core   +2 more sources

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster, Jae Woo Chung, Maria E. Linn‐Evans, Matthew N. Petrucci, Chiahao Lu, Destiny J. Weaver, Joshua De Kam, Scott E. Cooper, Paul J. Tuite, Aleksandar Videnovic, Michael J. Howell, Colum D. MacKinnon   +11 more
wiley   +1 more source

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

Communications Biology, 2022
Dopamine sensor cell lines expressing fluorescent reporters are developed. This versatile tool can record endogenous dopamine release from cultured neurons and striatal slices, determine dopamine tissue content, and detect dopamine uptake and efflux.
Carmen Klein Herenbrink, Jonatan Fullerton Støier, William Dalseg Reith, Abeer Dagra, Miguel Alejandro Cuadrado Gregorek, Reto B. Cola, Tommaso Patriarchi, Yulong Li, Lin Tian, Ulrik Gether, Freja Herborg   +10 more
doaj   +1 more source

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Shailesh Banerjee, Theodore Lidsky   +5 more
core   +1 more source

Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. [PDF]

, 2016
BackgroundCigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence.
London, Edythe D, Mandelkern, Mark A, Okita, Kyoji   +2 more
core   +2 more sources

RAB39B Related Parkinsonism in an Italian Family: A Unique Use of Advanced Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Parkinson's disease (PD) is a neurodegenerative disorder that may sometimes be caused by deleterious genetic variants. Among them, RAB39B polymorphisms are known as rare causes of early‐onset PD associated with intellectual disability (Waisman's syndrome).
Caterina Del Regno, Giovanni Ermanis, Christian Lettieri, Andrea Bernardini, Gaia Pellitteri, Enrico Belgrado, Elena Betto, Gian Luigi Gigli, David De Monte, Marco Domenico Scanni, Marco Mucchiut, Giuseppe Damante, Mariarosaria Valente, Francesco Janes   +13 more
wiley   +1 more source

Regulatory mechanisms of dopamine metabolism in a marine Meyerozyma guilliermondii GXDK6 under NaCl stress as revealed by integrative multi-omics analysis

Synthetic and Systems Biotechnology
Dopamine can be used to treat depression, myocardial infarction, and other diseases. However, few reports are available on the de novo microbial synthesis of dopamine from low-cost substrate. In this study, integrated omics technology was used to explore
Huijie Sun, Huashan Bai, Yonghong Hu, Sheng He, Ruihang Wei, Duotao Meng, Qiong Jiang, Hongping Pan, Peihong Shen, Qian Ou, Chengjian Jiang   +10 more
doaj   +1 more source

Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

Frontiers in Synaptic Neuroscience, 2018
This perspective article provides observations supporting the view that nigro-striatal dopamine neurons and meso-limbic dopamine neurons mainly communicate through short distance volume transmission in the um range with dopamine diffusing into ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Miguel Perez De La Mora, Paul Manger, Manuel Narváez, Sarah Beggiato, Minerva Crespo-Ramírez, Gemma Navarro, Karolina Wydra, Zaida Díaz-Cabiale, Alicia Rivera, Luca Ferraro, Sergio Tanganelli, Małgorzata Filip, Rafael Franco, Rafael Franco, Kjell Fuxe   +17 more
doaj   +1 more source

Dopamine receptors gene expression in male rat hippocampus after administration of MDMA (Ecstasy) [La Expresión Génica de Receptores de Dopamina en el Hipocampo de Ratas Macho Después de la Administración de MDMA (Éxtasis)] [PDF]

, 2015
Ecstasy is one of the most popular amusing drugs among young people. Documents indicate some effects of Ecstasy on hippocampus and close relations between dopaminergic functions with reward learning. Therefore, the aim of this study was evaluation of the
Kamran, H., Majid, S., Mehrdad, J., Simin, M.   +3 more
core