Results 71 to 80 of about 786,774 (402)
An expanded palette of dopamine sensors for multiplex imaging in vivo
Nature Methods, 2020 Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable high-resolution imaging of dopamine dynamics in behaving animals.
T. Patriarchi +12 more
semanticscholar +1 more source
The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging [PDF]
, 2006 Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in ...
Bernstein, HG +9 more
core +1 more source
Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors
Life, 2022 The dopaminergic system is one of the most important neurotransmitter systems in the central nervous system (CNS). It acts mainly by activation of the D1-like receptor family at the target cell. Additionally, fine-tuning of the signal is achieved via pre-synaptic modulation by the D2-like receptor family.
openaire +3 more sources
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John +5 more
wiley +1 more source
TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area [PDF]
, 2012 The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their involvement in intracellular Ca2+ regulation. Recently we reported their involvement in socialization and regulating anxiety-like behaviors in rats. Given
arxiv +1 more source
Mean-field modeling of the basal ganglia-thalamocortical system. I. Firing rates in healthy and parkinsonian states [PDF]
J. Theor. Biol. 257: 642-663 (2009), 2018 Parkinsonism leads to various electrophysiological changes in the basal ganglia-thalamocortical system (BGTCS), often including elevated discharge rates of the subthalamic nucleus (STN) and the output nuclei, and reduced activity of the globus pallidus external segment (GPe).
arxiv +1 more source
Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work
Science, 2019 Responsible use of psychostimulants Psychostimulants have a place in the therapy of attentional disorders. However, they are also widely used off-label to enhance cognitive performance, and their mechanisms of action remain elusive.
A. Westbrook +7 more
semanticscholar +1 more source
Prenatal Nicotine Exposure as a Teratogen in Neurological Pathways [PDF]
, 2016 Attention-deficit/hyperactivity disorder (ADHD) is the most heritable and commonly diagnosed childhood psychiatric disorder with 4% of all children being diagnosed with this disorder.
Grover, Monica
core +1 more source
Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking [PDF]
, 2013 Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood.
Baker, David A. +10 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source