Results 211 to 220 of about 1,754,831 (304)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Current and emerging drugs for Parkinson's disease: mechanisms, clinical evidence, and future directions. [PDF]

Front Pharmacol
Yang F.
europepmc   +1 more source

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source

Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats. [PDF]

Methods Protoc
Sysoev YI, Kurmazov NS, Shitc DD, Okovityi SV.   +3 more
europepmc   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

A computational pipeline for a neurotransmitter-centric analysis of the effects of psychiatric medication on EEG spectral power. [PDF]

Front Psychiatry
Zekerallah SS, Maxion AA, Zweerings J, Teucher P, Mathiak K, Kutafina E, Gaebler AJ.   +6 more
europepmc   +1 more source

Levodopa and Melanoma: Practical Recommendations for Parkinson's Disease—International Parkinson and Movement Disorder Society Scientific Issues Committee Viewpoint

Movement Disorders Clinical Practice, EarlyView.
Giorgia Sciacca, Inas Elsayed, Santiago Perez‐Lloret, Tiago F. Outeiro, Vivek K. Unni, Jeffery H. Kordower, Daniela Berg, Lorraine V. Kalia, on behalf of the MDS Scientific Issues Committee, Jane Alty, Alexander Balck, Daniela Berg, Per Borghammer, Inas Elsayed, Yue Huang, Walaa Kamel Elsayed, Jeffrey Kordower, Alexander Lehn, Michele Matarazzo, Tiago Mestre, Tiago Outeiro, Gian Pal, Santiago Perez Lloret, Roopa Rajan, Sephira Ryman, Giorgia Sciacca, Per Svenningsson, Lorraine Kalia   +27 more
wiley   +1 more source

Rheological and Mechanical Assessment of Injectable Hydrogels: A Framework for Structure–Property Analysis

Polymer Engineering &Science, EarlyView.
A rheological and mechanical assessment framework to construct structure‐property‐application relationships for injectable hydrogels. ABSTRACT Injectable hydrogels have attracted massive research attention thanks to their potential biomedical applications.
Hai Xin, D. S. Abdullah Al Maruf, Boyang Wan   +2 more
wiley   +1 more source

Electrospun conducting polymers: recent trends and the transition towards a sustainable future

Polymer International, EarlyView.
This review discusses the electrospinning of conducting polymers, detailing procedures, fibrous morphologies, improved properties, applications in electronics, and challenges, while outlining future directions for nanofibre‐based devices in various fields.
Xenofon Karagiorgis, Sofia Sandhu, Peter J. Skabara, Ravinder Dahiya   +3 more
wiley   +1 more source