Results 221 to 230 of about 88,842 (261)
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Inhibition of ribonucleotide reductase by antitumor agents related to levodopa and dopamine
Biochemical Pharmacology, 1985Using partially purified enzyme from L1210 cells, dihydroxybenzene derivatives related structurally to dopamine were shown to reversibly inactivate ribonucleotide reductase. A structure-activity analysis revealed that derivatives with side-chains, which contain a negatively-charged group, had significantly reduced inhibitory activity.
G B, FitzGerald, M M, Wick
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Vestibular compensation is affected by treatment with dopamine active agents.
Archives italiennes de biologie, 1993The aim of the present work was to examine the effects of postoperative treatments with agents active on dopaminergic system on vestibular recovery from the postural and ocular symptoms which follow a unilateral labyrinthectomy. Hemilabyrinthectomized guinea pigs were given a daily i.p.
PETROSINI, Laura, M. E. Dell'Anna
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Chapter 5. Dopamine Receptors and Dopaminergic Agents
1985Publisher Summary This chapter discusses the recent developments in the field of dopamine (DA) receptors and dopaminergic agents. Classification of DA receptors has been simplified considerably. Earlier receptor binding studies had indicated the existence of four distinct receptor subtypes, identified as D-1, D-2, D-3, and D-4. Evidence now indicates
John M. Schaus, James A. Clemens
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Posterior pituitary adenylate cyclase: stimulation by dopamine and other agents
Brain Research, 1979The posterior lobe of the pituitary gland contains dopaminergic and noradrenergic terminalsS,6, t4 as well as moderate levels of dopamine (DA) and norepinephrine is. In addition, the presence of receptors for DA in sheep posterior pituitary was indicated by binding studies employing [3H]-dihydroergocriptineS although negligible specific binding of ...
H S, Ahn, S C, Feldman, M H, Makman
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Effect of dopamine agents on schedule- and deprivation-induced drinking in rats
Pharmacology Biochemistry and Behavior, 1987The dopamine agonist, apomorphine, or its antagonist, haloperidol, was administered to rats whose drinking was induced by fixed-interval schedules of pellet delivery or by water deprivation. The first study revealed that both drugs produced dose-dependent decreases in bar-pressing and schedule-induced polydipsia (SIP). At higher doses, haloperidol also
S H, Snodgrass, J D, Allen
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Chapter 3. Antipsychotic Agents and Dopamine Agonists
1983Publisher Summary A large number of new compounds are being developed as anti-psychotics, many inspired by the atypical drugs clozapine and sulpiride. The emergence of selective presynaptic dopamine (DA) agonists instead of conventional DA blockers has increased strongly.
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Development of imaging agents for the dopamine transporter
Medicinal Research Reviews, 1995F I, Carroll +4 more
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The Importance of Dopamine D4 Receptors in the Action and Development of Antipsychotic Agents
Drugs, 1996The dopamine D4 receptor, recently identified by molecular biological techniques, is expressed in areas of the brain implicated in the pathophysiology of schizophrenia. Although it has a lower affinity than the D2 receptor for most antipsychotic drugs, the D4 receptor has a higher affinity for clozapine, which may explain the unique efficacy of ...
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Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine
Neuroscience & Biobehavioral Reviews, 2000Central nervous system processes are fundamental to sexual function. Considerable progress has been made in our understanding of the neuroanatomical and neuropharmacological bases for erection. Based largely on rat models, there is adequate understanding presently of the general anatomical areas of the brain that relate to sexual function, including ...
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Dopamine Pharmacological Agents in Resistant-OCD
Current Psychopharmacologye, 2012Stefano Pallanti +2 more
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