Results 21 to 30 of about 1,754,831 (304)

Dopamine’s secret agent: serotonin

Trends in Neurosciences
Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent-instituting a high-pass filter on striatal 'direct pathway' transmission-and does not require dopamine receptors.
Andrew J. Miller-Hansen, Talia N. Lerner
openaire   +3 more sources

Dopamine-Regulated Plasticity in MoO₃ Synaptic Transistors

, 2023
Field-effect transistor-based biosensors have gained increasing interest due to their reactive surface to external stimuli and the adaptive feedback required for advanced sensing platforms in biohybrid neural interfaces.
Duc Minh Tran (15059720), Chanyong Hwang (1467142), Jong Wan Son (1561339), Bae Ho Park (1560988), Tae-Seong Ju (8200758)   +4 more
core   +1 more source

An investigation into the function of single-neuron activity in the mesoaccumbens dopamine system of the rat [PDF]

, 2012
The mesoaccumbens dopamine system has been implicated in many basic psychological processes (e.g. "wanting" and "liking") and illnesses (e.g. addiction, depression, schizophrenia).
Wilson, David Ian Greig
core   +1 more source

De novo POLR2A p.(L1127F) variant presenting with neurodevelopmental regression and dystonia, with favorable response to low-dose dopamine therapy: a case report and literature review

Frontiers in Neuroscience
BackgroundNeurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities (NEDHIB) is a rare autosomal-dominant condition caused by pathogenic POLR2A variants.
Zhuci Cao, Qinru Shen, Chenchen Tangzhu, Xiaohui Guo, Qiwen Huang, Xin Ge, Qianlei Zhao, Xulai Shi, Xulai Shi   +8 more
doaj   +1 more source

Dopamine-Induced Oligomers of α‑Synuclein Inhibit Amyloid Fibril Growth and Show No Toxicity

, 2023
Parkinson’s disease is characterized by the selective death of dopaminergic neurons in the midbrain and accumulation of amyloid fibrils composed of α-synuclein (αSyn).
Tatiana Borisova (9033038), Maksym Galkin (7816772), Oleksandra Topcheva (15446060), Anastasiia Priss (10777831), Volodymyr V. Shvadchak (1285122)   +4 more
core   +1 more source

Tetrahydrocannabinol and Dopamine D1 Receptor [PDF]

, 2023
Dopamine is a hormone that is released by the adrenal gland and influences motor control and motivation. Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family. The D1
Jiwon, Lee
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

New generation antipsychotics in the treatment of schizophrenia: dopamine stabilizing agents and aripiprazole

Psychiatry and Clinical Psychopharmacology, 2021
Schizophrenia is a major mental disorder starting mostly during adolescence and cause significant disability. Positive and negative symptoms and cognitive dysfunctions are main domains of schizophrenia. Dopaminergic hyperactivation in mesolimbic regions
Köksal Alptekin
doaj  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Dorsal Striatum Dopamine Levels Fluctuate Across the Sleep–Wake Cycle and Respond to Salient Stimuli in Mice

Frontiers in Neuroscience, 2019
Dopamine is involved in numerous neurological processes, and its deficiency has been implicated in Parkinson’s disease, whose patients suffer from severe sleep disorders.
Hui Dong, Juan Wang, Yan-Fei Yang, Yan Shen, Yan Shen, Wei-Min Qu, Zhi-Li Huang   +6 more
doaj   +1 more source