Results 31 to 40 of about 554,589 (315)
Clinical Parkinsonism & Related Disorders, 2021 Dopamine agonists are one of the main stay of treatment option for Parkinson disease (PD). Side effects that develop from their use are generally categorized into behavioral and non-behavioral.
Mohammad Edrees Mohammad +6 more
doaj
Marine Drugs, 2019 The G protein-coupled receptor (GPCR) family of proteins comprises signaling proteins that mediate cellular responses to various hormones and neurotransmitters, and serves as a prime target for drug discovery.
Pradeep Paudel +5 more
doaj +1 more source
Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms
Frontiers in Endocrinology, 2022 Pituitary neuroendocrine tumors (PitNET) are commonly benign tumors accounting for 10-25% of intracranial tumors. Prolactin-secreting adenomas represent the most predominant type of all PitNET and for this subtype of tumors, the medical therapy relies on
Claudia Pivonello +9 more
doaj +1 more source
Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors
British Journal of Pharmacology, 2015 Rotigotine acts as a dopamine receptor agonist with high affinity for the dopamine D2, D3, D4 and D5 receptors but with a low affinity for the dopamine D1 receptor.
M. Wood +3 more
semanticscholar +1 more source
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
Resistant prolactinoma: Is it monoclonal or polyclonal?
Indian Journal of Endocrinology and Metabolism, 2013 Prolactinomas are solitary benign neoplasms and resistance to dopamine agonists occur in a small percentage of prolactinomas. Multiple pituitary adenomas are reported in less than 1% of pituitary adenomas and rarely result in resistant prolactinoma.
K. V. S. Hari Kumar, Pitambar Prusty
doaj +1 more source
Representation learning with reward prediction errors [PDF]
arXiv, 2021 The Reward Prediction Error hypothesis proposes that phasic activity in the midbrain dopaminergic system reflects prediction errors needed for learning in reinforcement learning. Besides the well-documented association between dopamine and reward processing, dopamine is implicated in a variety of functions without a clear relationship to reward ...
arxiv
Nature and Science of Sleep, 2023 Elliott Kyung Lee,1,2 Naomi Spitale,2,3 Rebecca Robillard2 1Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada; 2Sleep Research Unit, Institute for Mental Health Research (IMHR), Ottawa, Ontario, Canada; 3Department of Medicine ...
Lee EK, Spitale N, Robillard R
doaj
Management of prolactinoma during pregnancy and postpartum
Journal of Integrated Health Sciences, 2015 Prolactinoma is classified as microprolactinoma when it measures
Om J Lakhani +3 more
doaj +1 more source
Dopamine agonist‐responsive depression
Psychogeriatrics, 2013 Dopaminergic dysfunction is implicated in the pathophysiology of treatment‐resistant depression. In this review, we describe the putative role of dopamine in depression, summarize the evidence for the efficacy of dopamine receptor agonists in the ...
H. Hori, H. Kunugi
semanticscholar +1 more source