Results 51 to 60 of about 554,589 (315)

Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]

PLoS Comp. Biol. (2015) 11(2): e1004044, 2014
Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
arxiv   +1 more source

Reports of pathological gambling, hypersexuality, and compulsive shopping associated with dopamine receptor agonist drugs.

JAMA Internal Medicine, 2014
IMPORTANCE Severe impulse control disorders involving pathological gambling, hypersexuality, and compulsive shopping have been reported in association with the use of dopamine receptor agonist drugs in case series and retrospective patient surveys. These
T. Moore, Joseph Glenmullen, D. Mattison
semanticscholar   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Modeling ADHD in Drosophila: Investigating the Effects of Glucose on Dopamine Production Demonstrated by Locomotion [PDF]

arXiv, 2021
Hyperactivity is one of the hallmakrs of ADHD. Aberrant dopamine signaling is a major theme in ADHD and dopamine production is directly linked to the intensity and persistence of hyperactive conduct. The strength and persistence of hyperactivity responses in Drosophila to startle stimuli were measured in a study to determine the effects of sugar on ...
arxiv  

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

Cell Research, 2021
Dopamine is an essential neurotransmitter, which functions are mediated by five G protein-coupled receptors, dopamine D1 to D5 receptors (D1R-D5R) in mammals.
Y. Zhuang, B. Krumm, Huibing Zhang, X. E. Zhou, Yue Wang, Xi-Ping Huang, Yongfeng Liu, Xi Cheng, Yi Jiang, Hualiang Jiang, Cheng Zhang, W. Yi, B. Roth, Yan Zhang, H. Xu   +14 more
semanticscholar   +1 more source

Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe

Advanced Science, EarlyView.
A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang, Huiru Li, Yong Zhang, Xuhan Xia, Ningwen Zhang, Haixin Fan, Longhua Guo, Yongyong Cao, Hu Pan, Ruijie Deng, Yangang Wang, Rodrigo Ledesma‐Amaro, Jianguo Xu   +12 more
wiley   +1 more source

Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. [PDF]

PLoS ONE, 2011
Fear memory formation is thought to require dopamine, brain-derived neurotrophic factor (BDNF) and zinc release in the basolateral amygdala (BLA), as well as the induction of long term potentiation (LTP) in BLA principal neurons.
Chenchen Li, Joanna Dabrowska, Rimi Hazra, Donald G Rainnie   +3 more
doaj   +1 more source

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

Molecular Pharmacology, 2014
A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay.
R. Free, L. Chun, Amy E. Moritz, Brittney N. Miller, T. Doyle, Jennie L. Conroy, Adrian Padron, Julie A. Meade, Jingbo Xiao, Xin Hu, Andrés E Dulcey, Yang Han, L. Duan, S. Titus, Melanie Bryant-Genevier, E. Barnaeva, M. Ferrer, J. Javitch, T. Beuming, Lei Shi, Noel Southall, J. Marugan, D. Sibley   +22 more
semanticscholar   +1 more source

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Dopamine induces optical changes in the cichlid fish lens. [PDF]

PLoS ONE, 2010
The crystalline lens in the cichlid fish Aequidens pulcher undergoes a transformation of its optical properties every dawn and dusk as the eye adapts to changes in light conditions.
J Marcus Schartau, Ronald H H Kröger, Bodil Sjögreen   +2 more
doaj   +1 more source