Results 61 to 70 of about 554,589 (315)
Phasic dopamine release identification using ensemble of AlexNet [PDF]
arXiv, 2020 Dopamine (DA) is an organic chemical that influences several parts of behaviour and physical functions. Fast-scan cyclic voltammetry (FSCV) is a technique used for in vivo phasic dopamine release measurements. The analysis of such measurements, though, requires notable effort.
arxiv
Neuroreceptor Activation by Vibration-Assisted Tunneling [PDF]
Scientific Reports 5, Article number: 9990 Published 2015, 2015 G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous ...
arxiv +1 more source
Advanced Science, EarlyView.A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng +9 more
wiley +1 more source
Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves
Scientific Reports, 2020 Recent evidence suggests that the central nervous system (CNS) regulates plasma glucose levels, but the underlying mechanism is unclear. The present study investigated the role of dopaminergic function in the CNS in regulation of plasma glucose levels in
Hiroko Ikeda +8 more
doaj +1 more source
The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke
Brain : a journal of neurology, 2012 Hemispatial neglect following right-hemisphere stroke is a common and disabling disorder, for which there is currently no effective pharmacological treatment. Dopamine agonists have been shown to play a role in selective attention and working memory, two
N. Gorgoraptis +12 more
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao +6 more
wiley +1 more source
Clinical features of dopamine agonist withdrawal syndrome in a movement disorders clinic
Journal of Neurology Neurosurgery & Psychiatry, 2012 Background Recently, symptoms similar to addictive drug withdrawal have been reported in a structured longitudinal study of patients with idiopathic Parkinson's Disease (PD) withdrawing from dopamine agonists (DA): the dopamine agonist withdrawal ...
M. Pondal +10 more
semanticscholar +1 more source
Annals of Neurology, EarlyView.Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase +2 more
wiley +1 more source
Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease
Clinical Parkinsonism & Related Disorders, 2021 Introduction: Up to 40% of Parkinson’s disease patients taking dopamine agonist medication develop impulse control behaviors which can have severe negative consequences.
Alison Hall +5 more
doaj
D1 receptor agonist improves sleep–wake parameters in experimental parkinsonism
Neurobiology of Disease, 2014 Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy.
Carole Hyacinthe +4 more
doaj