Untreated Giant Macroprolactinoma with Chronic Cerebrospinal Fluid Leakage: An Unusual Complication
Case Reports in Endocrinology, 2019 Macroprolactinoma has the potential to cause base of skull erosion and often extends into the sphenoid sinus. Rapid shrinkage of this invasive tumor following dopamine agonist therapy has been postulated to cause unplugging of the eroded area, leading to
Mohamad Nazrulhisham Mad Naser +2 more
doaj +1 more source
Buprenorphine added on brief cognitive behavioral therapy for treatment of methamphetamine use disorder [PDF]
, 2018 Background: Methamphetamine (MA) use remains a major public health concern around the world. Recent findings suggest that buprenorphine may be helpful for cocaine use reduction. Moreover, animal studies described reduced dopamine peak effect following MA
Dean AJ +10 more
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Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome
Scientific ReportsMitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain complexes and have a variety of genetic variants or phenotypes. There are only a few approved treatments, and fundamental therapies are yet to be developed.
Mizuki Kobayashi +9 more
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Neurobiology of Disease, 2004 Brain cannabinoid CB1 receptors are expressed in neural areas that contribute to movement such as basal ganglia, where they co-localize with dopamine D1 and D2 receptors.
Fadwa El Banoua +4 more
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mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
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Neurobiology of Disease, 2006 Genetic and biochemical abnormalities associated with α-synuclein are implicated in the etiology of Parkinson's disease (PD). In this study, altered locomotor behavior linked to the expression of mutant or wildtype human α-synuclein was investigated ...
Erica L. Unger +6 more
doaj +1 more source
Herbal highs: review on psychoactive effects and neuropharmacology [PDF]
, 2017 Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S +5 more
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Simultaneous pyometra and viable puppies’ gestation in a bitch [PDF]
, 2014 Here we describe a case of pyometra coexisting with gestation in a 4.5 year-old miniature short-haired Dachshund. The dog exhibited depression, vaginal discharge, polydipsia and dehydration. Ultrasound examination revealed the presence of low to moderate
Corrada, Yanina Alejandra +2 more
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Effects of Dopamine Administration on Anxiety in Male Rat
مجله دانشکده پزشکی اصفهان, 2007 Background: Abstract Anxiety is a common disease in the society. Several neurotransmitters. The aim of this study was to investigate indirect effect of dopamine on anxiety in rat.
Hojatallah Alaei +4 more
doaj
Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]
, 2009 We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros +31 more
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