Results 81 to 90 of about 554,589 (315)

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

Molecular Informatics, Volume 42, Issue 1, January 2023., 2023
Abstract Many human diseases including cancer, degenerative and autoimmune disorders, diabetes and others are multifactorial. Pharmaceutical agents acting on a single target do not provide their efficient curation. Multitargeted drugs exhibiting pleiotropic pharmacological effects have certain advantages due to the normalization of the complex ...
O. A. Bocharova, N. S. Ionov, I. V. Kazeev, V. E. Shevchenko, E. V. Bocharov, R. V. Karpova, O. P. Sheychenko, A. A. Aksyonov, S. V. Chulkova, V. G. Kucheryanu, A. V. Revishchin, G. V. Pavlova, V. S. Kosorukov, D. A. Filimonov, A. A. Lagunin, V. B. Matveev, N. V. Pyatigorskaya, I. S. Stilidi, V. V. Poroikov   +18 more
wiley   +1 more source

Further SAR of GIRK1/2 activators: Synthesis and Biological Characterization of In Vitro Tool Compounds

ChemMedChem, Accepted Article.
The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany Spitznagel, Sandeep K Singh, Yashpal Chhonker, Daryl J Murry, David Weaver, Corey R Hopkins   +8 more
wiley   +1 more source

Melanin Made by Dopamine Oxidation: Thin Films and Interactions with Polyelectrolyte Multilayers [PDF]

arXiv, 2014
The spontaneous oxidation of dopamine in slightly alkaline solutions was investigated on the basis of the work of Lee and others [Science, 318:426-430, 2007], and the reaction product was identified as dopamine-melanin. The ability of melanin to covalently bind amine functional groups was confirmed by quantification of the corresponding binding sites ...
arxiv  

Association of dopamine agonist use with impulse control disorders in Parkinson disease.

Archives of Neurology, 2006
OBJECTIVE To determine the frequency and correlates of impulse control disorders (ICDs) in Parkinson disease (PD). DESIGN An unstructured screening interview for ICDs (compulsive gambling, buying, and sexual behavior) followed by a telephone ...
D. Weintraub, A. Siderowf, M. Potenza, J. Goveas, K. Morales, J. Duda, P. Moberg, M. Stern   +7 more
semanticscholar   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2].
Shamia L. Faison, Joelle Batonga, Thangam Arumugham, Angela Bartkus, Marion Morrison, Mark J. Mullin, Tim Tippin, Odin Naderer   +7 more
wiley   +1 more source

A review of frequently used Kampo prescriptions part 1. Daikenchuto

Traditional &Kampo Medicine, Volume 9, Issue 3, Page 151-179, December 2022., 2022
Abstract Background The original formula name for daikenchuto (DKT) was written in ‘Jin Gui Yao Lue (Kinkiyōryaku in Japanese)’. DKT as used in Japan consists of four types of crude drug. Key findings Although there are few examples of its use in Chinese classical records, it has begun to be used extensively in modern Japan for intestinal obstruction ...
Takao Namiki, Takayuki Hoshino, Nobuaki Egashira, Toshiaki Kogure, Mari Endo, Masato Homma   +5 more
wiley   +1 more source

Circadian‐timed dopamine agonist treatment reverses high‐fat diet‐induced diabetogenic shift in ventromedial hypothalamic glucose sensing

Endocrinology, Diabetes & Metabolism, 2020
Introduction Within the ventromedial hypothalamus (VMH), glucose inhibitory (GI) neurons sense hypoglycaemia while glucose excitatory (GE) neurons sense hyperglycaemia to initiate counter control mechanisms under normal conditions.
Carl R. Stoelzel, Yahong Zhang, Anthony H. Cincotta   +2 more
doaj   +1 more source

Electronic schematic for bio-plausible dopamine neuromodulation of eSTDP and iSTDP [PDF]

arXiv, 2018
In this technical report we present novel results of the dopamine bio-plausible neuromodulation excitatory (eSTDP) and inhibitory (iSTDP) learning. We present the principal schematic for the neuromodulation of D1 and D2 receptors of dopamine, wiring schematic for both cases as well as the simulatory experiments results done in LTSpice.
arxiv