Results 101 to 110 of about 103,481 (331)

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat [PDF]

, 1999
The main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area.
Altman, Blaha, Brog, Campbell, Carlezon, Cuffel, Devenport, Douglas, Edmonds, Falkai, Fibiger, Fibiger, Fiorino, Fonnum, Fuller, Glickman, Groenewegen, Guy Mittleman, Hawkins, Hodos, Hodos, Jarrard, Jarrard, Kelley, Koob, Koob, Kovelman, Kramarcy, LeDuc, Liebman, Markou, Miliaressis, Mittleman, Olton, Phillips, Phillips, Ranaldi, Schaub, Schmelzeis, Sengstake, Sesack, Siegel, Stephen P. Kelley, Stewart, Sutherland, Taylor, Totterdell, Valenstein, Walass, Whishaw, Wilkinson, Witkin, Yang   +52 more
core   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, EarlyView.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

Effects of dance therapy on balance, gait and neuro-psychological performances in patients with Parkinson's disease and postural instability [PDF]

, 2012
Postural Instability (PI) is a core feature of Parkinson’s Disease (PD) and a major cause of falls and disabilities. Impairment of executive functions has been called as an aggravating factor on motor performances. Dance therapy has been shown effective
Agnetti, Virgilio, Aiello, Elena, De Natale, Edoardo, Deriu, Franca, Paulus, Kai Stephan, Sotgiu, Giovanni, Tolu, Eusebio   +6 more
core  

A double-blind study of the efficacy of apomorphine and its assessment in "off-periods in Parkinson's disease [PDF]

, 1993
Five patients with idiopathic Parkinson's disease with severe response fluctuations were selected for a randomized double-blind placebo-controlled study, concerning the clinical effects of subcutaneous apomorphine and its assessment in `off¿-periods. The
Essink, A.W.G., Jansen, E.N.H., Laar, T. van, Neef, C., Oosterloo, S.   +4 more
core   +3 more sources

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Pramipexole use and the risk of pneumonia

BMC Neurology, 2012
Background Patients with Parkinson's disease have an elevated risk of pneumonia and randomized trials suggest that this risk may be increased with the dopamine agonist pramipexole.
Ernst Pierre, Renoux Christel, Dell'Aniello Sophie, Suissa Samy   +3 more
doaj   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Activation of Dopamine D4 Receptors Is Protective Against Hypoxia/ Reoxygenation-Induced Cell Death in HT22 Cells

Journal of Pharmacological Sciences, 2010
Several reports have shown that some dopamine receptor ligands modulate the ischemia–reperfusion injury in animal models; however, its underling mechanisms are still unclear. In this study, we sought to establish an in vitro experimental model of hypoxia/
Saori Shimada, Mioko Hirabayashi, Kumiko Ishige, Yasuhiro Kosuge, Tetsuro Kihara, Yoshihisa Ito   +5 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

ChemistryEurope, EarlyView.
Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai   +11 more
wiley   +1 more source