Results 131 to 140 of about 103,481 (331)

The Impact of Deep Brain Stimulation of the Subthalamic Nucleus on Sleep–Wake Function and Circadian Rhythms in Patients with Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well‐established therapy in advanced Parkinson's disease (PD) improving motor and non‐motor signs including sleep. The mechanisms of sleep improvement are insufficiently understood.
Julia Steinhardt   +6 more
wiley   +1 more source

A Real‐World Study on Unstable Parkinson's Disease: Levodopa Dosage Management and the Role of Nonmotor Symptoms

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a neurodegenerative disorder associated with motor and nonmotor symptoms. Objectives This study assesses levodopa dose management, the therapeutic goals of clinicians, the factors that influence clinicians' choice of therapy, and the role of nonmotor symptoms using real‐world evidence from Germany, Italy,
Fabrizio Stocchi   +2 more
wiley   +1 more source

MPTP-induced degeneration: interference with glutamatergic toxicity [PDF]

open access: yes, 1994
Parkinson's disease (PD) is characterised by the progressive degeneration of nigrostriatal dopamine (DA) neurons resulting in the major symptoms of akinesia and rigidity.
Lange, Klaus W.   +3 more
core  

Observed and Patient‐Perceived Information Provision When Diagnosed With Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background People with Parkinson's disease (PD) perceive to receive insufficient disease‐specific information after diagnosis, whereas clinicians report providing all relevant information. Objectives The objectives were to examine the information actually provided by clinicians during diagnostic consultations and its relations with background ...
Elisabeth Kurpershoek   +10 more
wiley   +1 more source

Levodopa‐Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the COSMOS Study

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Dyskinesia is a debilitating complication of dopaminergic therapy in advanced Parkinson's disease. Objectives To evaluate the effect of levodopa‐carbidopa intestinal gel (LCIG) on dyskinesia burden. Methods This is a post hoc analysis of the retrospective, observational COmedication Study assessing Mono‐ and cOmbination therapy with
Alfonso Fasano   +11 more
wiley   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

open access: yes, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Investigation of the Determinants of Disease Severity in Patients with Idiopathic Normal Pressure Hydrocephalus

open access: yesMovement Disorders Clinical Practice, EarlyView.
Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder   +3 more
wiley   +1 more source

Dopamine agonists and risk of lung cancer in patients with restless legs syndrome. [PDF]

open access: yesPharmacoepidemiol Drug Saf, 2023
Hernandez-Con P   +3 more
europepmc   +1 more source

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