Results 1 to 10 of about 45,564 (148)

Using cocaine and apomorphine self-administration in rats to measure the pharmacokinetics of competitive dopamine receptor antagonists administered by different routes [PDF]

Scientific Reports
Cocaine self-administration behavior in rats is explained by a pharmacokinetic/pharmacodynamic interaction model. This self-administration model represents a pharmacological bioassay system that can measure the pharmacokinetics and the pharmacodynamic ...
Heather J. Song, Jhanvi N. Desai, Mantana K. Norman, Andrew B. Norman   +3 more
doaj   +2 more sources

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Pharmaceuticals, 2023
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients.
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kokot, Antun Koprivanac, Ivan Dobric, Marko Sever, Mario Staresinic, Lovorka Batelja Vuletic, Anita Skrtic, Sven Seiwerth   +24 more
doaj   +1 more source

Systemic blockade of dopamine D2-like receptors increases high-voltage spindles in the globus pallidus and motor cortex of freely moving rats. [PDF]

PLoS ONE, 2013
High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus ...
Chen Yang, Shun-Nan Ge, Jia-Rui Zhang, Lei Chen, Zhi-Qiang Yan, Li-Jun Heng, Tian-Zhi Zhao, Wei-Xin Li, Dong Jia, Jun-Ling Zhu, Guo-Dong Gao   +10 more
doaj   +1 more source

Combined α2- and D2-receptor blockade activates noradrenergic and dopaminergic neurons, but extracellular dopamine in the prefrontal cortex is determined by uptake and release from noradrenergic terminals

Frontiers in Pharmacology, 2023
Experimental and clinical evidence indicates a deficit of release and function of dopamine in schizophrenia and suggests that α2-adrenoceptor antagonists rescue dopamine deficit and improve the antipsychotic efficacy of D2-receptor antagonists.
Claudia Sagheddu, Paola Devoto, Paola Devoto, Sonia Aroni, Pierluigi Saba, Pierluigi Saba, Marco Pistis, Marco Pistis, Marco Pistis, Gian Luigi Gessa, Gian Luigi Gessa, Gian Luigi Gessa   +11 more
doaj   +1 more source

Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken [PDF]

Archives of Razi Institute, 2021
The present study aimed to identify the role of dopaminergic and cannabinoidergic systems in the ghrelin-induced hypophagia among meat-type chickens.
R Farrokhi, V Babapour, M Zendehdel, A Asghari, H Gilanpour   +4 more
doaj   +1 more source

Polypharmacology of dopamine D1-like receptor antagonists [PDF]

Arhiv za farmaciju, 2015
Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases ...
Nikolić Katarina, Filipić Slavica, Agbaba Danica   +2 more
doaj   +1 more source

The Interaction of Dopaminergic System and GABAB Receptor in Food Intake Regulation of Neonatal Chicken [PDF]

Poultry Science Journal, 2022
Animal studies have shown the role of gamma amino butyric acid (GABAergic) and Dopaminergic systems in controlling appetite, but their interactions in birds have not yet been investigated . In this study, 6 experiments were carried out to investigate the
Mona Hashemzadeh, Moteza Zendehdel, Vahab Babapour, Negar Panahi   +3 more
doaj   +1 more source

Dopamine influences attentional rate modulation in Macaque posterior parietal cortex

Scientific Reports, 2022
Cognitive neuroscience has made great strides in understanding the neural substrates of attention, but our understanding of its neuropharmacology remains incomplete.
Jochem van Kempen, Christian Brandt, Claudia Distler, Mark A. Bellgrove, Alexander Thiele   +4 more
doaj   +1 more source

Dopamine Has a Critical Role in Photoreceptor Degeneration in the rd Mouse

Neurobiology of Disease, 2002
Photoreceptors receive paracrine input from dopaminergic interplexiform cells. Rod photoreceptors in the rd mouse degenerate rapidly due to a specific gene defect.
Judith Mosinger Ogilvie, Judith D. Speck
doaj   +1 more source

Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats

Journal of Pharmacological Sciences, 2011
.: A better understanding of the neurochemical mechanisms mediating the aversive consequences of drug withdrawal is important for understanding drug addiction. We previously demonstrated that the inhibitory effect of glutamate receptor antagonists on the
Yoichi Kawasaki, Hiroaki Araki, Katsuya Suemaru, Yoshihisa Kitamura, Yutaka Gomita, Toshiaki Sendo   +5 more
doaj   +1 more source