Results 21 to 30 of about 282,920 (297)

The Pharmacologic Treatment of Stuttering and Its Neuropharmacologic Basis

Frontiers in Neuroscience, 2020
Stuttering is a DSM V psychiatric condition for which there are no FDA-approved medications for treatment. A growing body of evidence suggests that dopamine antagonist medications are effective in reducing the severity of stuttering symptoms.
Gerald A. Maguire, Diem L. Nguyen, Kevin C. Simonson, Troy L. Kurz   +3 more
doaj   +1 more source

Aminoalkylindoles: atypical dopamine antagonists

Journal of Pharmacy and Pharmacology, 1983
AbstractThe neuropharmacological profile of a series of aminoalkylindole compounds (AHR-1229-(3-[2-(3-indolyl)-ethyl]-butylamino-1-phenyl-pyrrolidine), AHR1771-(1-[2-(2-methyl-3-indolyl)ethyl]-4-phenyl-3,4-dehydropiperidine), AHR1806-(1-[2-(5-chloro-3-indolyl)-ethyl]-4-phenyl-3,4-dehydropiperidine), AHR1858-(1-[2-(3-indolyl)ethyl]-4-(4-fluorophenyl)-1 ...
B, Costall, W N, Dannenburg, D N, Johnson, R J, Naylor   +3 more
openaire   +2 more sources

Differential impact of N-Methyl-D-Aspartate Receptor antagonists on genes involved in synaptic plasticity and neural glucose metabolism: implication for psychosis. [PDF]

, 2011
Background: NMDA-R-hypofunction (NRH) is considered one of the putative molecular mechanism involved in psychosis. Several studies show that an imbalance of dopamine–glutamate transmission has a key role in psychosis pathophysiology.
Sarappa, Chiara
core   +1 more source

New information of dopaminergic agents based on quantum chemistry calculations

Scientific Reports, 2020
Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson’s disease and Huntington’s disease ...
Guillermo Goode-Romero, Ulrika Winnberg, Laura Domínguez, Ilich A. Ibarra, Rubicelia Vargas, Elisabeth Winnberg, Ana Martínez   +6 more
doaj   +1 more source

Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System

Frontiers in Psychiatry, 2021
The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression.
Heinz Grunze, Heinz Grunze, Réka Csehi, Christoph Born, Christoph Born, Ágota Barabássy   +5 more
doaj   +1 more source

Pharmacological Evidence That Dopamine Inhibits the Cardioaccelerator Sympathetic Outflow via D2-Like Receptors in Pithed Rats

Journal of Pharmacological Sciences, 2013
It has been suggested that N,N-di-n-propyl-dopamine (dopamine analogue) decreased heart rate in rats through stimulation of dopamine receptors. Nevertheless, the role of prejunctional dopamine D1/2-like receptors or even α2-adrenoceptors to mediate ...
Oscar Alcántara-Vázquez, Ma. Trinidad Villamil-Hernández, Araceli Sánchez-López, David Centurión   +3 more
doaj   +1 more source

Hemichorea after hypoglycemic episodes with negative MRI findings in an elderly woman with poorly controlled type 2 diabetes mellitus: a case report

BMC Neurology, 2019
Background Diabetic chorea appears during the course of poorly-controlled diabetes. While chorea associated with diabetes mellitus usually occurs during hyperglycemic episodes, hypoglycemia can also cause diabetic chorea. Brain magnetic resonance imaging
Eriko Matsushima, Hiroshi Shiota, Kentaro Watanabe, Yuichiro Otsuka, Midori Yamana, Suguru Yamaguchi, Fujiko Egashira, Satoshi Kamei, Hisamitsu Ishihara   +8 more
doaj   +1 more source

The dopaminergic system is able to modulate the central histamine-induced pressor effect in hemorrhage-shocked rats

Annales Academiae Medicae Silesiensis
Introduction: Histamine administered intracerebroventricularly (icv) induces a resuscitating effect in hemorrhage-shocked rats. Dopamine receptors are present in neuronal pathways involved in central cardiovascular regulation; therefore, the aim of the ...
Karolina Jasikowska, Magdalena Zając, Alessandra Ottani, Daniela Giuliani , Salvatore Guarini, Jerzy Jochem   +5 more
doaj   +1 more source

A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research

Frontiers in Pharmacology, 2018
The origins of the major classes of current anti-emetics are examined. Serendipity is a recurrent theme in discovery of their anti-emetic properties and repurposing from one indication to another is a continuing trend.
Gareth J. Sanger, Paul L. R. Andrews
doaj   +1 more source

Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia

, 2002
The findings that dopamine D3 and D4 receptors are highly expressed in limbic and cortical areas (D4 more than D3), and the fact that the atypical drug clozapine has preferential affinity for the D4 receptors have suggested an involvement of these ...
Grillner, P,, Svensson, TH, Jardemark, K,, Wadenberg, M-L   +3 more
core   +5 more sources