Results 31 to 40 of about 282,920 (297)

A Role for Sigma Receptors in Stimulant Self Administration and Addiction

Pharmaceuticals, 2011
Sigma1 receptors (σ1Rs) represent a structurally unique class of intracellular proteins that function as chaperones. σ1Rs translocate from the mitochondria-associated membrane to the cell nucleus or cell membrane, and through protein-protein interactions
Shang-Yi Tsai, Theresa Kopajtic, Takato Hiranita, Teruo Hayashi, Gianluigi Tanda, Jonathan L. Katz, Tsung-Ping Su   +6 more
doaj   +1 more source

Dopamine restores reward prediction errors in old age [PDF]

, 2013
Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value ...
Dayan, P., Dolan, Raymond J, Dayan, P, Dolan, R., Huys, Q., Guitart-Masip, M. ; https://orcid.org/, Düzel, E., Rumana Chowdhury, Chowdhury, R., Christian Lambert, Emrah Düzel, Duezel, Emrah, Guitart-Masip, M., Dolan, Raymond J., Lambert, C., Lambert, C, Chowdhury, Rumana, Chowdhury, R, Guitart-Masip, Marc,, Guitart-Masip, Marc, Dolan, RJ, Marc Guitart-masip, Düzel, E, Dolan, R. ; https://orcid.org/, Raymond J Dolan, Peter Dayan, Dayan, Peter, Guitart-Masip, M, Düzel, Emrah, Huys, Q, Lambert, Christian, Quentin Huys, Huys, Quentin   +32 more
core   +1 more source

Managing and treating Sydenham chorea: A systematic review

Brain and Behavior, 2023
Introduction Sydenham's chorea (SC), prevalent in developing countries and occasionally affecting developed ones, poses a clinical challenge due to the lack of systematic guidelines for diagnosis and treatment.
Samiuddin Tariq, Faizan Niaz, Summaiyya Waseem, Taha Gul Shaikh, Syed Hassan Ahmed, Muhammad Irfan, Abdulqadir J. Nashwan, Irfan Ullah   +7 more
doaj   +1 more source

Dopamine receptor subtypes and ingestive behaviour [PDF]

, 1999
Both centrally and systemically administered dopamine agonists and antagonists decrease ingestive behaviour. The aim of this thesis was to examine whether drugs acting at different receptor subtypes decreased intake in different ways.
Genn, Rachel F., Genn, R.F.
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Effect of best practice advisory on the administration of contraindicated medications to hospitalized patients with Parkinson’s disease and related disorders

Frontiers in Aging Neuroscience, 2023
ObjectiveTo determine the effect of a Best Practice Advisory (BPA) on the ordering and administration of contraindicated dopamine blocking agents (DBA) to hospitalized patients with Parkinson’s disease (PD) and related disorders.BackgroundPatients with ...
Natalia Chunga, Katherine Amodeo, Katherine Amodeo, Melanie Braun, Blanca Y. Valdovinos, Irene H. Richard, Irene H. Richard   +6 more
doaj   +1 more source

Ventilatory Stimulation by Dopamine-Receptor Antagonists in the Mouse [PDF]

Survey of Anesthesiology, 1985
Ventilation was measured by a plethysmographic method in awake mice before and after intraperitoneal injection of neuroleptic drugs to test the hypothesis that dopaminergic mechanisms modulate control of breathing in this species. Dose‐dependent augmentation of ventilation at rest and during hypoxia, and reduced ventilation during hypercapnia was ...
L G, Olson, N A, Saunders
openaire   +2 more sources

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

An Extremely Rare Case of Gastroptosis Treated Successfully with Itopride in a Patient with Parkinson’s Disease

Nigerian Postgraduate Medical Journal
A rare condition known as gastroptosis causes the major curvature of the stomach to shift downward and towards the pelvis. While some are asymptomatic, others experience symptoms. Cross-sectional imaging, or barium X-rays, are diagnostic.
Kübra Yildiz Cömert, Alper Tuna Güven
doaj   +1 more source