Results 11 to 20 of about 282,920 (297)

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer [PDF]

, 2023
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the ...
Brugarolas Campillos, Marc, Cortés Tejedor, Antonio, Bonaventura, Jordi, Navarro Brugal, Gemma, Lluís i Biset, Carme, Rea, William, Moreno Guillén, Estefanía, Canela Campos, Enric I. (Enric Isidre), 1949-, Schiffmann, Serge N., Mallol Montero, Josefa, Azdad, Karima, Casadó, Vicent, Casadó Anguera, Verònica, Volkow, Nora D., Ferré, Sergi   +14 more
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Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists [PDF]

, 2021
: The dopamine receptor 4 (D4R) is highly expressed in both motor, associative and limbic subdivisions of the coritico-basal ganglia network. Due to the distribution in the brain, there is mounting evidence pointing to a role for the D4R in the ...
Anish, Vadukoot, Corey, Hopkins, Kirsten, Tolentino, Viktoriya, Mashinson   +3 more
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Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior [PDF]

, 2001
Stimuli paired with primary rewards can acquire emotional valence and the ability to elicit automatic, Pavlovian approach responses that have been shown to be mediated by the nucleus accumbens. The present experiment investigated the effects of infusions
Rudolf N. Cardinal, Di Ciano, Patricia, Patricia Di Ciano, Cowell, Rosemary A., Rosie A. Cowell, Barry J. Everitt, Cardinal, Rudolf N., Simon J. Little, Little, Simon J., Everitt, Barry J.   +9 more
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Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex [PDF]

, 2008
In the subthalamic nucleus (STN) of Parkinson’s disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15–30 Hz) accompanies movement difficulties.
Sharott, A, Bolam, JP, Pogosyan, A, Magill, PJ, Brown, P, Mallet, N, Csicsvari, J   +6 more
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Endothelium‐derived dopamine modulates EFS‐induced contractions of human umbilical vessels

Pharmacology Research & Perspectives, 2020
Electrical field stimulation (EFS) induces contractions of both snake aorta and human umbilical cord vessels (HUCV) which were dependent on the presence of the endothelium.
José Britto‐Júnior, David H. A. Pinheiro, Alberto F. O. Justo, Guilherme M. Figueiredo Murari, Rafael Campos, Fernanda V. Mariano, Valéria B. deSouza, André A. Schenka, Fabiola Z. Mónica, Edson Antunes, Gilberto De Nucci   +10 more
doaj   +1 more source

Structure and Function Studies of the Human Dopamine Receptors [PDF]

, 2004
Dopamine neurotransmitter and its receptors play a critical role in cell signaling process responsible for information transfer in neurons functioning in the nervous system.
Kalani, M. Yashar S.
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Neuroprotection by dopamine agonists [PDF]

, 1994
Research on Parkinson's disease has led to new hypotheses concerning the mechanisms of neurodegeneration and to the development of neuroprotective agents.
Rausch, W. D., Naumann, M., Riederer, P., Oestreicher, E., Lange, Klaus W., Gsell, W.   +5 more
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Acetaminophen improves tardive akathisia induced by dopamine D2 receptor antagonists [PDF]

, 2023
Tardive akathisia is a movement disorder characterized by internal restlessness with an uncontrollable urge to move, leading to repetitive movements. It is a common side effect of long-term treatment with dopamine D2 receptor antagonists.
Shuji Kaneko, Kaneko, Shuji, Koki Nagaoka, Kazuki Nagayasu, Hisashi Shirakawa, Nagayasu, Kazuki, Nagaoka, Koki, Shirakawa, Hisashi   +7 more
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A quantum chemical approach representing a new perspective concerning agonist and antagonist drugs in the context of schizophrenia and Parkinson's disease.

PLoS ONE, 2019
Schizophrenia and Parkinson's disease can be controlled with dopamine antagonists and agonists. In order to improve the understanding of the reaction mechanism of these drugs, in this investigation we present a quantum chemical study of 20 antagonists ...
Ana Martínez, Ilich A Ibarra, Rubicelia Vargas   +2 more
doaj   +1 more source

Apo-ghrelin receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain

Frontiers in Endocrinology, 2014
The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS).
Andras eKern, Cristina eGrande, Roy G Smith   +2 more
doaj   +1 more source