Results 11 to 20 of about 45,985 (264)

Endothelium‐derived dopamine modulates EFS‐induced contractions of human umbilical vessels

Pharmacology Research & Perspectives, 2020
Electrical field stimulation (EFS) induces contractions of both snake aorta and human umbilical cord vessels (HUCV) which were dependent on the presence of the endothelium.
José Britto‐Júnior, David H. A. Pinheiro, Alberto F. O. Justo, Guilherme M. Figueiredo Murari, Rafael Campos, Fernanda V. Mariano, Valéria B. deSouza, André A. Schenka, Fabiola Z. Mónica, Edson Antunes, Gilberto De Nucci   +10 more
doaj   +1 more source

Aminoalkylindoles: atypical dopamine antagonists

Journal of Pharmacy and Pharmacology, 1983
AbstractThe neuropharmacological profile of a series of aminoalkylindole compounds (AHR-1229-(3-[2-(3-indolyl)-ethyl]-butylamino-1-phenyl-pyrrolidine), AHR1771-(1-[2-(2-methyl-3-indolyl)ethyl]-4-phenyl-3,4-dehydropiperidine), AHR1806-(1-[2-(5-chloro-3-indolyl)-ethyl]-4-phenyl-3,4-dehydropiperidine), AHR1858-(1-[2-(3-indolyl)ethyl]-4-(4-fluorophenyl)-1 ...
B, Costall, W N, Dannenburg, D N, Johnson, R J, Naylor   +3 more
openaire   +2 more sources

A quantum chemical approach representing a new perspective concerning agonist and antagonist drugs in the context of schizophrenia and Parkinson's disease.

PLoS ONE, 2019
Schizophrenia and Parkinson's disease can be controlled with dopamine antagonists and agonists. In order to improve the understanding of the reaction mechanism of these drugs, in this investigation we present a quantum chemical study of 20 antagonists ...
Ana Martínez, Ilich A Ibarra, Rubicelia Vargas   +2 more
doaj   +1 more source

The Pharmacologic Treatment of Stuttering and Its Neuropharmacologic Basis

Frontiers in Neuroscience, 2020
Stuttering is a DSM V psychiatric condition for which there are no FDA-approved medications for treatment. A growing body of evidence suggests that dopamine antagonist medications are effective in reducing the severity of stuttering symptoms.
Gerald A. Maguire, Diem L. Nguyen, Kevin C. Simonson, Troy L. Kurz   +3 more
doaj   +1 more source

Apo-ghrelin receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain

Frontiers in Endocrinology, 2014
The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS).
Andras eKern, Cristina eGrande, Roy G Smith   +2 more
doaj   +1 more source

Reducing Addiction in Bipolar Disorder via Hacking the Dopaminergic System

Frontiers in Psychiatry, 2021
The dopaminergic system plays a central and decisive role in substance use disorder (SUD), bipolar disorder (BD), and possibly in a subgroup of patients with refractory depression.
Heinz Grunze, Heinz Grunze, Réka Csehi, Christoph Born, Christoph Born, Ágota Barabássy   +5 more
doaj   +1 more source

New information of dopaminergic agents based on quantum chemistry calculations

Scientific Reports, 2020
Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson’s disease and Huntington’s disease ...
Guillermo Goode-Romero, Ulrika Winnberg, Laura Domínguez, Ilich A. Ibarra, Rubicelia Vargas, Elisabeth Winnberg, Ana Martínez   +6 more
doaj   +1 more source

Pharmacological Evidence That Dopamine Inhibits the Cardioaccelerator Sympathetic Outflow via D2-Like Receptors in Pithed Rats

Journal of Pharmacological Sciences, 2013
It has been suggested that N,N-di-n-propyl-dopamine (dopamine analogue) decreased heart rate in rats through stimulation of dopamine receptors. Nevertheless, the role of prejunctional dopamine D1/2-like receptors or even α2-adrenoceptors to mediate ...
Oscar Alcántara-Vázquez, Ma. Trinidad Villamil-Hernández, Araceli Sánchez-López, David Centurión   +3 more
doaj   +1 more source

Hemichorea after hypoglycemic episodes with negative MRI findings in an elderly woman with poorly controlled type 2 diabetes mellitus: a case report

BMC Neurology, 2019
Background Diabetic chorea appears during the course of poorly-controlled diabetes. While chorea associated with diabetes mellitus usually occurs during hyperglycemic episodes, hypoglycemia can also cause diabetic chorea. Brain magnetic resonance imaging
Eriko Matsushima, Hiroshi Shiota, Kentaro Watanabe, Yuichiro Otsuka, Midori Yamana, Suguru Yamaguchi, Fujiko Egashira, Satoshi Kamei, Hisamitsu Ishihara   +8 more
doaj   +1 more source

The dopaminergic system is able to modulate the central histamine-induced pressor effect in hemorrhage-shocked rats

Annales Academiae Medicae Silesiensis
Introduction: Histamine administered intracerebroventricularly (icv) induces a resuscitating effect in hemorrhage-shocked rats. Dopamine receptors are present in neuronal pathways involved in central cardiovascular regulation; therefore, the aim of the ...
Karolina Jasikowska, Magdalena Zając, Alessandra Ottani, Daniela Giuliani , Salvatore Guarini, Jerzy Jochem   +5 more
doaj   +1 more source