Results 1 to 10 of about 2,920,633 (193)
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
Frontiers in Pharmacology, 2020 Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition.
Jean Claude Martel +1 more
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Dopamine Receptor Signaling [PDF]
Journal of Receptors and Signal Transduction, 2004 The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf ...
Kim A, Neve +2 more
openaire +3 more sources
Science-Business eXchange, 2012 Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
R. Turco
openaire +2 more sources
Frontiers in Aging Neuroscience, 2019 Background: The dopaminergic system has been associated with the progression of Alzheimer's disease. But previous studies found inconsistent results regarding the relationship between Alzheimer's disease and dopamine when looking at dopamine receptor ...
Xiongfeng Pan +9 more
doaj +2 more sources
Structural insights into the human D1 and D2 dopamine receptor signaling complexes.
Cell, 2021 The D1- and D2-dopamine receptors (D1R and D2R), which signal through Gs and Gi, respectively, represent the principal stimulatory and inhibitory dopamine receptors in the central nervous system.
Y. Zhuang +21 more
semanticscholar +1 more source
KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant. [PDF]
PLoS ONE, 2015 DOPAMINE D4 RECEPTOR POLYMORPHISM:The dopamine D4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit hyperactivity ...
Kamila Skieterska +3 more
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Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions
Pharmaceuticals, 2023 Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement.
Diego Guidolin +6 more
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Structure of a D2 dopamine receptor-G protein complex in a lipid membrane
Nature, 2020 The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease 1 and antipsychotic drugs 2 . DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine 3 , leading to stimulation of G ...
Jie Yin +8 more
semanticscholar +1 more source
Identification of novel target molecules of l-menthol
Heliyon, 2021 The present study used a binding assay to identify novel target biomolecules of l-menthol ([−]-menthol) that promote mouse ambulation. Among 88 different ligands to specific biomolecules examined, 0.1 mM l-menthol inhibited the binding of 13 ligands with
Toyoshi Umezu
doaj +1 more source
The Journal of Headache and Pain, 2022 Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine.
Wei Zhang +6 more
doaj +1 more source