Results 1 to 10 of about 303,848 (355)

KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant. [PDF]

PLoS ONE, 2015
DOPAMINE D4 RECEPTOR POLYMORPHISM:The dopamine D4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit hyperactivity ...
Kamila Skieterska, Pieter Rondou, Béatrice Lintermans, Kathleen Van Craenenbroeck   +3 more
doaj   +14 more sources

Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions

Pharmaceuticals, 2023
Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement.
Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Chiara Cervetto, Raffaele De Caro, Guido Maura, Luigi F. Agnati   +6 more
doaj   +1 more source

Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine

The Journal of Headache and Pain, 2022
Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine.
Wei Zhang, Ming Lei, Qianwen Wen, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lixue Chen   +6 more
doaj   +1 more source

Identification of novel target molecules of l-menthol

Heliyon, 2021
The present study used a binding assay to identify novel target biomolecules of l-menthol ([−]-menthol) that promote mouse ambulation. Among 88 different ligands to specific biomolecules examined, 0.1 mM l-menthol inhibited the binding of 13 ligands with
Toyoshi Umezu
doaj   +1 more source

Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]

, 2020
Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S., Cardarelli, S., D'angelo, V., Fusco, F. R., Giorgi, M., Mercuri, N. B., Paldino, E., Sancesario, G., Sorge, R.   +8 more
core   +1 more source

Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken [PDF]

Archives of Razi Institute, 2021
The present study aimed to identify the role of dopaminergic and cannabinoidergic systems in the ghrelin-induced hypophagia among meat-type chickens.
R Farrokhi, V Babapour, M Zendehdel, A Asghari, H Gilanpour   +4 more
doaj   +1 more source

Dopamine D1/D5 Receptor Signaling Is Involved in Arrhythmogenesis in the Setting of Takotsubo Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
BackgroundPrevious studies suggested involvement of non-ß-adrenoceptors in the pathogenesis of Takotsubo cardiomyopathy (TTC). This study was designed to explore possible roles and underlying mechanisms of dopamine D1/D5 receptor coupled signaling in ...
Mengying Huang, Zhen Yang, Yingrui Li, Huan Lan, Lukas Cyganek, Lukas Cyganek, Goekhan Yuecel, Goekhan Yuecel, Goekhan Yuecel, Siegfried Lang, Siegfried Lang, Siegfried Lang, Karen Bieback, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Xiaobo Zhou, Xiaobo Zhou, Xiaobo Zhou, Xiaobo Zhou, Martin Borggrefe, Martin Borggrefe, Martin Borggrefe, Ibrahim Akin, Ibrahim Akin, Ibrahim Akin   +25 more
doaj   +1 more source

Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

PLoS ONE, 2013
Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals.
Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada   +8 more
doaj   +1 more source

Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice [PDF]

, 2008
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not
Atkins, Baik, Battisti, Battisti, Boileau, Cador, Chiang, Crabbe, Crawford, de Wit, Down, Fleckenstein, Gabbay, Glickstein, Hamamura, Jones, Kalivas, Kamens, Karler, Karper, Kelly, Kelly, Kilty, Kuczenski, Kuribara, Kuribara, Kuribara, McDougall, Neve, Palmer, Phillips, Phillips, Pierce, Robinson, Ron, Rubinstein, Sax, Schmauss, Shen, Tanabe, Ujike, Vezina, Vezina, Xu, Xu, Xu, Xu, Yates   +47 more
core   +1 more source

Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5

Neoplasia: An International Journal for Oncology Research, 2023
Recent studies indicate that signaling molecules traditionally associated with central nervous system function play critical roles in cancer. Dopamine receptor signaling is implicated in various cancers including glioblastoma (GBM) and it is a recognized
Hye-Min Jeon, Young Taek Oh, Yong Jae Shin, Nakho Chang, Donggeun Kim, Donghun Woo, Yoon Yeup, Kyeung Min Joo, Heejin Jo, Heekyoung Yang, Jin-Ku Lee, Wonyoung Kang, Jason Sa, Won Jun Lee, James Hale, Justin D. Lathia, Benjamin Purow, Myung Jin Park, Jong Bae Park, Do-Hyun Nam, Jeongwu Lee   +20 more
doaj   +1 more source