α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Application of generative autoencoder in de novo molecular design [PDF]
arXiv, 2017 A major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning methodology, for de novo molecular design.
arxiv
Further Evidence for Inhibition of Episodic Luteinizing Hormone Release in Ovariectomized Rats by Stimulation of Dopamine Receptors1 [PDF]
, 1977 Sophia V. Drouva, Robert V. Gallo
openalex +1 more source
From Lab to Life: Self‐Powered Sweat Sensors and Their Future in Personal Health Monitoring
Advanced Science, EarlyView.This review focuses on recent advances in self‐powered sweat sensors in personal health monitoring, including sweat sensors, energy harvesters, energy management, and their applications. It analyzes the difficulties and challenges in the research field of self‐powered sweat sensors and looks into the future direction of self‐powered sweat sensors from ...
Nan Gao +3 more
wiley +1 more source
CORE: Automatic Molecule Optimization Using Copy & Refine Strategy [PDF]
arXiv, 2019 Molecule optimization is about generating molecule $Y$ with more desirable properties based on an input molecule $X$. The state-of-the-art approaches partition the molecules into a large set of substructures $S$ and grow the new molecule structure by iteratively predicting which substructure from $S$ to add.
arxiv
VASCULAR DOPAMINE RECEPTORS IN THE CANINE HINDLIMB [PDF]
, 1975 Christopher Bell +3 more
openalex +1 more source
Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury
Advanced Science, EarlyView.Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang +5 more
wiley +1 more source
Serum prolactin as an index of dopamine receptor blockade in acute schizophrenia [proceedings] [PDF]
, 1977 P. Mary Cotes, TJ Crow, EC Johnstone
openalex +1 more source
Electrical Microneedles for Wound Treatment
Advanced Science, EarlyView.A review on state‐of‐art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted.
Yu Wang +6 more
wiley +1 more source
Leveraging 13C NMR spectroscopic data derived from SMILES to predict the functionality of small biomolecules by machine learning: a case study on human Dopamine D1 receptor antagonists [PDF]
arXivThis study contributes to ongoing research which aims to predict small biomolecule functionality using Carbon-13 Nuclear Magnetic Resonance ($^{13}$C NMR) spectrum data and machine learning (ML). The approach was demonstrated using a bioassay on human dopamine D1 receptor antagonists.
arxiv