Results 31 to 40 of about 303,848 (355)

D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD

Neurobiology of Disease, 2010
Low doses of psychostimulants produce beneficial behavioral effects in ADHD patients but the mechanisms underlying the response are not understood. Here we use the hyperactive mouse mutant coloboma to identify D2-like dopamine receptor subtypes that ...
Xueliang Fan, Ming Xu, Ellen J. Hess
doaj   +1 more source

Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats

Biomolecules & Biomedicine, 2013
While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir, Ihsan Bagcivan, Sinan Gursoy   +2 more
doaj   +1 more source

Novel Mutation Detection of Regulatory Molecule Dopamine Gene Receptors (D1–D5) Encoding Analysis on Human Peripheral Blood Lymphocytes in Schizophrenia Patients

European Journal of Inflammation, 2009
There is much evidence which highlights the involvement of the dopamine system in the pathophysiology of schizophrenia. Recently, there have been reports of detected mutations in dopamine gene receptors in genomic DNA of schizophrenia.
G. Ahangari MT, PhD, G.H. Shariati, M.R. Asadi, M.R. Ostadali, H.R. Ahmadkhaniha   +4 more
doaj   +1 more source

Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients

BMC Medical Genetics, 2001
Background Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to limited accessibility to dopamine receptor. The purpose of this study was to define whether
Choi Chul-Hee, Koo Min-Seong, Kwak Yong T, Sunwoo IN   +3 more
doaj   +1 more source

Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens

Molecular Brain, 2022
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune system.
Daisuke Sato, Yusuke Hamada, Michiko Narita, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Kenichi Tanaka, Sara Yoshida, Hideki Tamura, Akihiro Yamanaka, Emiko Senba, Naoko Kuzumaki, Minoru Narita   +12 more
doaj   +1 more source

Normal spatial learning and improved spatial working memory in mice (mus musculus) lacking dopamine d4 receptors [PDF]

, 2001
Dopamine terminals in the hippocampus and prefrontal cortex modulate cognitive processes such as spatial learning and working memory. Because dopamine D4 receptors are expressed in these brain areas we have analyzed mutant mice lacking this receptor ...
Avale, Maria Elena, Falzone, Tomas Luis, Gelman, Diego Matias, Rubinstein, Marcelo   +3 more
core   +1 more source

Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors [PDF]

, 2010
Methylphenidate (MP) and amphetamine (AMPH) are the most frequently prescribed medications for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Bermeo, C., Grandy, David K., Rubinstein, Marcelo, Suchland, K. L., Thanos, P. K., Volkow, N. D., Wang, G. J.   +6 more
core   +1 more source

Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors

Frontiers in Synaptic Neuroscience, 2018
This perspective article provides observations supporting the view that nigro-striatal dopamine neurons and meso-limbic dopamine neurons mainly communicate through short distance volume transmission in the um range with dopamine diffusing into ...
Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Dasiel O. Borroto-Escuela, Miguel Perez De La Mora, Paul Manger, Manuel Narváez, Sarah Beggiato, Minerva Crespo-Ramírez, Gemma Navarro, Karolina Wydra, Zaida Díaz-Cabiale, Alicia Rivera, Luca Ferraro, Sergio Tanganelli, Małgorzata Filip, Rafael Franco, Rafael Franco, Kjell Fuxe   +17 more
doaj   +1 more source

Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence. [PDF]

, 2015
BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions.
Ballard, Michael E, Dean, Andy C, Hsu, Eustace, Ishibashi, Kenji, London, Edythe D, Mandelkern, Mark A, Monterosso, John R, Robertson, Chelsea L   +7 more
core   +3 more sources

Activation of Dopamine D4 Receptors Is Protective Against Hypoxia/ Reoxygenation-Induced Cell Death in HT22 Cells

Journal of Pharmacological Sciences, 2010
Several reports have shown that some dopamine receptor ligands modulate the ischemia–reperfusion injury in animal models; however, its underling mechanisms are still unclear. In this study, we sought to establish an in vitro experimental model of hypoxia/
Saori Shimada, Mioko Hirabayashi, Kumiko Ishige, Yasuhiro Kosuge, Tetsuro Kihara, Yoshihisa Ito   +5 more
doaj   +1 more source