Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors [PDF]
, 2010 Methylphenidate (MP) and amphetamine (AMPH) are the most frequently prescribed medications for the treatment of attention-deficit/hyperactivity disorder (ADHD).
Bermeo, C. +6 more
core +1 more source
The Dopamine/Neuroleptic Receptor [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1984 ABSTRACTThe neuroleptic/dopamine receptor, with its picomolar affinity for potent neuroleptics, is the functional dopamine receptor of the brain. This receptor has been termed the D2dopamine receptor, and it inhibits or interferes with dopamine-stimulated adenylate cyclase.
Dimitri Grigoriadis, Philip Seeman
openaire +3 more sources
Frontiers in Psychiatry, 2011 Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc ...
Helga eHöifödt Lidö +4 more
doaj +1 more source
Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]
PLoS ONE, 2014 Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang +4 more
doaj +1 more source
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]
arXiv, 2022 Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv
Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation [PDF]
, 2006 ©2006 Society for NeurosciencePrevious studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons.
Ferré, Sergi +6 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau +12 more
wiley +1 more source
Cardiovascular Dopamine Receptors: Role of Renal Dopamine and Dopamine Receptors in Sodium Excretion [PDF]
Pharmacology & Toxicology, 1990 Research efforts in the area of peripheral dopamine have now established the presence of two distinct subtypes--DA1 and DA2--of DA receptors, and have identified a potential role for dopamine produced within the kidney in the control of renal sodium excretion.
Sharath S. Hegde, Mustafa F. Lokhandwala
openaire +3 more sources
Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. [PDF]
PLoS ONE, 2016 Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex.
Rajesh Narendran +7 more
doaj +1 more source
Novel psychoactive substances (NPS) – knowledge and experiences of drug users from Hungary, Poland, the UK and the USA [PDF]
, 2020 Submitted 19 September 2019; Accepted 29 November 2019; Proof received 29 November 2019; Published 18 February 2020. Note: No DOI allocated.Dopamine D 3 receptor partial agonists represent a new generation of atypical antipsychotics.
Corazza, Ornella +11 more
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