Results 51 to 60 of about 156,081 (291)
Advanced Healthcare Materials, EarlyView.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey +5 more
wiley +1 more source
Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5
Neoplasia: An International Journal for Oncology Research, 2023 Recent studies indicate that signaling molecules traditionally associated with central nervous system function play critical roles in cancer. Dopamine receptor signaling is implicated in various cancers including glioblastoma (GBM) and it is a recognized
Hye-Min Jeon +20 more
doaj
Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. [PDF]
PLoS ONE, 2009 The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the
Stéphane Doly +9 more
doaj +1 more source
Electronic schematic for bio-plausible dopamine neuromodulation of eSTDP and iSTDP [PDF]
arXiv, 2018 In this technical report we present novel results of the dopamine bio-plausible neuromodulation excitatory (eSTDP) and inhibitory (iSTDP) learning. We present the principal schematic for the neuromodulation of D1 and D2 receptors of dopamine, wiring schematic for both cases as well as the simulatory experiments results done in LTSpice.
arxiv
Advanced Materials, EarlyView.Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll +16 more
wiley +1 more source
High level modeling of tonic dopamine mechanisms in striatal neurons [PDF]
arXiv, 2007 The extant versions of many basal ganglia models use a `gating' model of dopamine function which enhances input to D1 receptor units and attenuates input to D2 receptor units. There is evidence that this model is unsatisfactory because (a) there are not sufficient dopaminergic synapses to gate all input and (b) dopamine's main effect is likely to be on
arxiv
A deep-learning view of chemical space designed to facilitate drug discovery [PDF]
arXiv, 2020 Drug discovery projects entail cycles of design, synthesis, and testing that yield a series of chemically related small molecules whose properties, such as binding affinity to a given target protein, are progressively tailored to a particular drug discovery goal.
arxiv
Analysis of training and seed bias in small molecules generated with a conditional graph-based variational autoencoder -- Insights for practical AI-driven molecule generation [PDF]
arXiv, 2021 The application of deep learning to generative molecule design has shown early promise for accelerating lead series development. However, questions remain concerning how factors like training, dataset, and seed bias impact the technology's utility to medicine and computational chemists.
arxiv
Advanced Materials, EarlyView.Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li +3 more
wiley +1 more source