Results 61 to 70 of about 156,081 (291)
Frontiers in Psychiatry, 2013 Cocaine addiction is accompanied by a decrease in striatal dopamine signaling, measured as a decrease in dopamine D2 receptor binding as well as blunted dopamine release in the striatum. These alterations in dopamine transmission have clinical relevance,
Pierre eTrifilieff +2 more
doaj +1 more source
D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis
Frontiers in Molecular Neuroscience, 2020 Dopamine, alongside other neuromodulators, defines brain and neuronal states, inter alia through regulation of global and local mRNA translation. Yet, the signaling pathways underlying the effects of dopamine on mRNA translation and psychiatric disorders
Orit David +6 more
doaj +1 more source
In-Pocket 3D Graphs Enhance Ligand-Target Compatibility in Generative Small-Molecule Creation [PDF]
arXiv, 2022 Proteins in complex with small molecule ligands represent the core of structure-based drug discovery. However, three-dimensional representations are absent from most deep-learning-based generative models. We here present a graph-based generative modeling technology that encodes explicit 3D protein-ligand contacts within a relational graph architecture.
arxiv
Advanced Materials, EarlyView.Twenty‐one biopolymer electrolytes including membrane‐liquid electrolytes, gel electrolytes, and solid electrolytes are synthesized to analyze their electrochemical properties and environmental impacts through life cycle assessment. This consistent and comparable study demonstrates the significant functional and environmental benefits of biopolymer ...
Jing Huang +4 more
wiley +1 more source
Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
Cell Reports, 2015 Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson’s disease (PD) and psychiatric disorders.
Stephanie C. Gantz +4 more
doaj +1 more source
DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications
Advanced Materials, EarlyView.DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding +5 more
wiley +1 more source
Progress in the study of Dopamine Receptor Agonists for Brain Protection after Ischemic Brain Injury
Zhongguo cuzhong zazhi: Ischemic brain injury comprises 87% of all brain injuries and typically results in severe functional impairments. Dopamine, the most abundant catecholamine neurotransmitter in the brain, is intimately linked with autonomous movement, emotion, sleep ...
ZHANG Linyao1, LIU Lixu1,2
doaj +1 more source
Electrospinning and Nanofiber Technology: Fundamentals, Innovations, and Applications
Advanced Materials, EarlyView.This review explores electrospinning fundamentals, methods for synthesizing polymer, metal oxide, carbon, and composite nanofibers, and advancements in fiber architectures like porous, core–shell, and aligned structures. It highlights applications in functional membranes, sensors, energy systems, and catalyst design while addressing future ...
Yujang Cho +5 more
wiley +1 more source
Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules
Advanced Materials Interfaces, EarlyView.This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania +2 more
wiley +1 more source
Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia [PDF]
arXiv, 2019 Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression
arxiv