Results 111 to 120 of about 121,521 (304)

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action

Journal of Pharmacology and Experimental Therapeutics, 2019
For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to avoid the limiting side effects of dopamine receptor blockade, has failed to date ...
N. Dedic, Philip G. Jones, S. Hopkins, R. Lew, Liming Shao, J. E. Campbell, K. Spear, T. Large, U. Campbell, T. Hanania, E. Leahy, K. Koblan   +11 more
semanticscholar   +1 more source

Positive Reinforcement Mediated by Midbrain Dopamine Neurons Requires D1 and D2 Receptor Activation in the Nucleus Accumbens

PLoS ONE, 2014
The neural basis of positive reinforcement is often studied in the laboratory using intracranial self-stimulation (ICSS), a simple behavioral model in which subjects perform an action in order to obtain exogenous stimulation of a specific brain area ...
Elizabeth E Steinberg, Josiah R. Boivin, Benjamin T. Saunders, Ilana B. Witten, K. Deisseroth, P. Janak   +5 more
semanticscholar   +1 more source

CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior. [PDF]

Front Behav Neurosci, 2023
Fernandes L, Kleene R, Congiu L, Freitag S, Kneussel M, Loers G, Schachner M.   +6 more
europepmc   +1 more source

Positive Effects of Caffeine Therapy in a Girl with PDE2A‐Related Paroxysmal Dyskinesia

Movement Disorders Clinical Practice, EarlyView.
Katerina Bernardi, Moritz Thiel, Anne Koy   +2 more
wiley   +1 more source

The Impact of Metformin on Weight and Waist Circumference in Patients Treated With Clozapine: A One‐Year Retrospective Cohort Study

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Metformin shows potential in combating clozapine‐induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine‐treated patients and its impact on weight and waist circumference (WC).
Bee Leng Per, Susan Loeser, Suzanne Edwards, Wen Siew Lee, Lisa R. Wilton, Scott Richard Clark   +5 more
wiley   +1 more source

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer. [PDF]

Cancer Biol Ther, 2023
Paraghamian SE, Qiu J, Hawkins GM, Zhao Z, Sun W, Fan Y, Zhang X, Suo H, Hao T, Prabhu VV, Allen JE, Zhou C, Bae-Jump V.   +12 more
europepmc   +1 more source

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Science, 2010
Tweaking Dopamine Reception Dopamine modulates many cognitive and emotional functions of the human brain by activating G protein–coupled receptors. Antipsychotic drugs that block two of the receptor subtypes are used to treat schizophrenia but have ...
E. Chien, Wei Liu, Qiang Zhao, V. Katritch, Gye Won Han, M. Hanson, Lei Shi, A. Newman, J. Javitch, V. Cherezov, R. Stevens   +10 more
semanticscholar   +1 more source

Exploring the Link Between Headache, Possible Sleep Bruxism and Self‐Medication in Adolescents

Acta Paediatrica, EarlyView.
ABSTRACT Aim Adolescents predominantly suffer from headaches and sleep bruxism. Yet, the association between both conditions remains unclear. This study investigated the relationship between primary headaches and possible sleep bruxism in adolescents. Methods A cross‐sectional study was conducted from August 24 to October 13, 2022, with 567 adolescents
M. C. P. do Nascimento, J. F. O. L. Batista, L. G. L. Júnior, S. S. da Silva, G. P. Falcão, M. V. Heimer   +5 more
wiley   +1 more source