Results 11 to 20 of about 48,073 (302)
Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats
Biomolecules & Biomedicine, 2013 While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir +2 more
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Frontiers in Neuroanatomy, 2011 Dopaminergic signaling within the basal ganglia has classically been thought to occur within two distinct neuronal pathways; the direct striatonigral pathway which contains the dopamine D1 receptor and the neuropeptides dynorphin and substance P, and the
Melissa L. Perreault +7 more
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Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. [PDF]
PLoS ONE, 2016 Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex.
Rajesh Narendran +7 more
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Frontiers in Pharmacology, 2022 Cast immobilization causes sensory hypersensitivity, which is also a symptom of neuropathic pain and chronic pain. However, the mechanisms underlying immobilization-induced hypersensitivity remain unclear.
Yuki Kishikawa +7 more
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Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence [PDF]
Brazilian Journal of Medical and Biological Research, 2015 Meningiomas are common, usually benign tumors, with a high postoperative recurrence rate. However, the genesis and development of these tumors remain controversial.
G. Trott +5 more
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Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]
PLoS ONE, 2013 The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
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Antisera specific for D2 dopamine receptors [PDF]
Biochemical Journal, 1993 Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine ...
Andrew J. Doherty +2 more
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Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
Cell Reports, 2015 Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson’s disease (PD) and psychiatric disorders.
Stephanie C. Gantz +4 more
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Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors
eLife, 2017 The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely characterized.
Brooks G Robinson +5 more
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Molecular dynamics of dopamine at the D2 receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 A three-dimensional model of the dopamine D2 receptor, assumed to be a target of antipsychotic drug action, was constructed from its amino acid sequence. The model was based on structural similarities within the super-family of guanine nucleotide-binding regulatory (G) protein-coupled neuroreceptors and has seven alpha-helical transmembrane segments ...
Ingebright Sylte +2 more
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