Purification of brain D2 dopamine receptor. [PDF]
The EMBO Journal, 1988 D2 dopamine receptors have been extracted from bovine brain using the detergent cholate and purified approximately 20,000-fold by affinity chromatography on haloperidol-sepharose and wheat germ agglutinin-agarose columns. The purified preparation contains D2 dopamine receptors as judged by the pharmacological specificity of [3H]spiperone binding to the
Williamson, RA +3 more
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Activation of D1 and D2 dopamine receptors increases the activity of the somatostatin receptor-effector system in the rat frontoparietal cortex [PDF]
, 2000 The role of dopamine D1 and D2 receptor subtypes in the regulation, in vivo, of the somatostatin (SRIF) receptor-effector system in rat frontoparietal cortex was investigated.
Arilla Ferreiro, Eduardo +2 more
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Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]
, 2020 Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S. +8 more
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Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers. [PDF]
PLoS ONE, 2013 Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine
Gemma Navarro +13 more
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Synaptotagmin-1 is a Ca2+ sensor for somatodendritic dopamine release
Cell Reports, 2023 Summary: Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads to D2 receptor-induced modulation of dopamine neurons on the timescale of ...
Joseph J. Lebowitz +5 more
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Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]
PLoS ONE, 2014 Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang +4 more
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D2 dopamine receptor gene and obesity [PDF]
International Journal of Eating Disorders, 1994 The prevalence of Taql A D2 dopamine receptor (DRD2) alleles was determined in 73 obese women and men. In this sample with a mean body mass index of 35.1, the A1 (minor) allele of the DRD2 gene was present in 45.2% of these nonalcohol, nondrug abusing subjects. The DRD2 A1 allele was not associated with a number of cardiovascular risk factors examined,
Terry Ritchie +8 more
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Frontiers in Endocrinology, 2020 Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu +15 more
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Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. [PDF]
, 2016 BackgroundCigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence.
London, Edythe D +2 more
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D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD
Neurobiology of Disease, 2010 Low doses of psychostimulants produce beneficial behavioral effects in ADHD patients but the mechanisms underlying the response are not understood. Here we use the hyperactive mouse mutant coloboma to identify D2-like dopamine receptor subtypes that ...
Xueliang Fan, Ming Xu, Ellen J. Hess
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