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Aspects of the structure of the D2 dopamine receptor
Trends in Neurosciences, 1990Significant new information on the D2 dopamine receptor has recently become available from a combination of protein chemical and molecular genetic analyses. Molecular genetic studies have shown the receptor to be a member of the family of receptors that are linked to G proteins and that have structures predicted to contain seven transmembrane domains ...
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Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides
Biochemical and Biophysical Research Communications, 1996Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues. Photoaffinity labelling experiments confirmed that D2 receptors exist either as monomers that are selective targets for spiperone or as dimers that are targets ...
Mark R. Brann +6 more
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D2 Dopamine Receptors and Schizophrenia
1991The dopamine hypothesis of schizophrenia postulates that an elevation of the D2 dopamine receptor density could be part of the pathophysiology of the disease. To assess this question, in vivo studies of the D2 receptors have been performed in drug-free schizophrenics using positron emission tomography.
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Olfactory receptor neurons express D2 dopamine receptors
The Journal of Comparative Neurology, 1999The role of the dopamine (DA) in the olfactory bulb (OB) was explored by determining which of the potential target cells express dopamine receptors (DARs). Previously, it was reported that D2-like DAR (D2, D3, and D4 subtypes) radioligand binding is restricted to the outer layers of the OB.
Adam C. Puche +6 more
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D2 dopamine receptor localization on striatonigral neurons
Neuroscience Letters, 1992Two major pharmacological classes of dopamine receptors exist in the central nervous system. These receptors have been designated as D1 or D2 based upon their differing pharmacology and influence on the cyclic AMP second messenger system. Different genes for the D1 and D2 dopamine receptors have been isolated and are found to be expressed in high ...
David R. Sibley +3 more
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Neurobiological Features of Dopamine D2 Receptors
2002Two different isoforms of the dopamine D2 receptor exist in vivo, named D2L and D2S. These isoforms are derived by alternative splicing of the sixth exon of the gene (Dal Toso et al., 1989; Giros et al., 1989). D2L is the longer isoform composed of 444 amino acids (aa) in rat (Monsma et al., 1989; Chio et al., 1990) and mouse (Montmayeur et al., 1991 ...
Ciro Iaccarino +2 more
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Isolation and characterization of D2-dopamine receptors
Biochemical Society Transactions, 1985Strange, PG +3 more
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Dopamine D2 Receptors as Treatment Targets in Schizophrenia
Clinical Schizophrenia & Related Psychoses, 2010The antipsychotic effectiveness of chlorpromazine and haloperidol started a search for their therapeutic targets. The antipsychotic receptor target turned out to be a dopamine receptor, now cloned as the dopamine D2 receptor. The D2 receptor is the common target for antipsychotics.
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
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