Results 21 to 30 of about 121,521 (304)
Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence [PDF]
Brazilian Journal of Medical and Biological Research, 2015 Meningiomas are common, usually benign tumors, with a high postoperative recurrence rate. However, the genesis and development of these tumors remain controversial.
G. Trott +5 more
doaj +3 more sources
Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]
PLoS ONE, 2013 The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
doaj +1 more source
Precision Medical Sciences, Volume 11, Issue 4, Page 146-154, December 2022., 2022 Toward precision nutrition: Genetic risks of nutrients deficiencies and eating behaviors among the Orang Asli and Malays. Abstract This cross‐sectional study aimed to profile 15 genetic markers associated with the risks of nutrient deficiencies and eating disinhibition behaviors that could lead to obesity among the Orang Asli (OA) and the Malays.
Nurul Ain Khoruddin +5 more
wiley +1 more source
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv +1 more source
Brain : a journal of neurology, 2009 Dopamine D2 receptor signalling is strongly implicated in the aetiology of schizophrenia. We have recently characterized the function of three DRD2 SNPs: rs12364283 in the promoter affecting total D2 mRNA expression; rs2283265 and rs1076560, respectively
A. Bertolino +13 more
semanticscholar +1 more source
Neurodevelopment in school‐aged children after intrauterine exposure to antipsychotics
Acta Psychiatrica Scandinavica, Volume 147, Issue 1, Page 43-53, January 2023., 2023 Abstract Objective Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long‐term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school‐aged children.
Lisanne Schrijver +8 more
wiley +1 more source
Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1.
Human Molecular Genetics, 2007 Ataxin 1 (Atxn1) is a protein of unknown function associated with spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disease of late onset with variable degrees of cerebellar ataxia, ophthalmoplegia and neuropathy.
R. Goold +7 more
semanticscholar +1 more source
Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
Cell Reports, 2015 Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson’s disease (PD) and psychiatric disorders.
Stephanie C. Gantz +4 more
doaj +1 more source
Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
Andrology, Volume 11, Issue 2, Page 379-398, February 2023., 2023 Abstract Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million.
Ankit Desai +4 more
wiley +1 more source
Structure of a D2 dopamine receptor-G protein complex in a lipid membrane
Nature, 2020 The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease 1 and antipsychotic drugs 2 . DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine 3 , leading to stimulation of G ...
Jie Yin +8 more
semanticscholar +1 more source