Results 21 to 30 of about 99,139 (322)
Frontiers in Pharmacology, 2022 Cast immobilization causes sensory hypersensitivity, which is also a symptom of neuropathic pain and chronic pain. However, the mechanisms underlying immobilization-induced hypersensitivity remain unclear.
Yuki Kishikawa +7 more
doaj +1 more source
Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. [PDF]
, 2015 Dysfunction of the mesocorticolimbic system has a critical role in clinical features of addiction. Despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in ...
Dean, AC +5 more
core +4 more sources
Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. [PDF]
PLoS ONE, 2016 Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex.
Rajesh Narendran +7 more
doaj +1 more source
Clinical Parkinsonism & Related Disorders, 2023 Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor ...
Stuart H. Isaacson +4 more
doaj +1 more source
Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence [PDF]
Brazilian Journal of Medical and Biological Research, 2015 Meningiomas are common, usually benign tumors, with a high postoperative recurrence rate. However, the genesis and development of these tumors remain controversial.
G. Trott +5 more
doaj +3 more sources
Antisera specific for D2 dopamine receptors [PDF]
Biochemical Journal, 1993 Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine ...
P L, Chazot, A J, Doherty, P G, Strange
openaire +2 more sources
Voltage sensitivity of dopamine D2-like receptors [PDF]
, 2011 G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core +1 more source
Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]
, 2009 We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros +31 more
core +3 more sources
Journal of Pharmacological Sciences, 2010 Among the various dopamine receptors, D2-like receptors (D2R, D3R, and D4R) are characterized by a large third cytoplasmic loop, a short carboxyl-terminal tail, and the ability to activate inhibitory G proteins.
Norifumi Shioda +2 more
doaj +1 more source
Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]
PLoS ONE, 2013 The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
doaj +1 more source