Results 31 to 40 of about 169,368 (383)

Voltage sensitivity of dopamine D2-like receptors [PDF]

, 2011
G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core   +1 more source

Dopamine Receptor D2 and Associated microRNAs Are Involved in Stress Susceptibility and Resistance to Escitalopram Treatment

International Journal of Neuropsychopharmacology, 2015
Background: Early life stress has been demonstrated to increase the risk of developing depression in adulthood. However, the roles and associated molecular mechanisms of stresses in the onset and relapse of depression have yet to be fully elucidated ...
Yi Zhang, Yuting Wang, Lei Wang, Mei Bai, Xiuwu Zhang, Xiongzhao Zhu   +5 more
semanticscholar   +1 more source

Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]

PLoS ONE, 2013
The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
doaj   +1 more source

Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]

, 2009
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros, Cho, D. A. Dougherty, Dougherty, Dougherty, Dougherty, Doupnik, Gallivan, H. A. Lester, Hibert, Hopkins, Huang, Huang, K. S. Bower, Klabunde, Kofuji, Krapivinsky, Lagerstrom, Lu, Lu, M. M. Torrice, Ma, Mark, Nemeth, Nowak, Palczewski, Rasmussen, Schwartz, Warne, Xiu, Zacharias, Zhong   +31 more
core   +3 more sources

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma

OncoTarget, 2014
Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular ...
Jie Li, Shan Zhu, D. Kozono, K. Ng, D. Futalan, Ying Shen, J. Akers, Tyler C. Steed, D. Kushwaha, M. Schlabach, B. Carter, C. Kwon, F. Furnari, W. Cavenee, S. Elledge, Clark C. Chen   +15 more
semanticscholar   +1 more source

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors

Journal of Pharmacological Sciences, 2010
Among the various dopamine receptors, D2-like receptors (D2R, D3R, and D4R) are characterized by a large third cytoplasmic loop, a short carboxyl-terminal tail, and the ability to activate inhibitory G proteins.
Norifumi Shioda, Yusuke Takeuchi, Kohji Fukunaga   +2 more
doaj   +1 more source

Dual role of dopamine D2-like receptors in the mediation of conditioned and unconditioned fear [PDF]

, 2012
A reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system, particularly the amygdala, clearly reduces conditioned fear.
Brandão, Marcus Lira, de Oliveira, Amanda Ribeiro, Muthuraju, Sangu, Colombo, Ana Caroline, Saito, Viviane Mitsuko, Talbot, Teddy   +5 more
core   +4 more sources

Effects on turning of microinjections into basal ganglia of D1 and D2 dopamine receptors agonists and the cannabinoid CB1 antagonist SR141716A in a rat Parkinson's model

Neurobiology of Disease, 2004
Brain cannabinoid CB1 receptors are expressed in neural areas that contribute to movement such as basal ganglia, where they co-localize with dopamine D1 and D2 receptors.
Fadwa El Banoua, Isabel Caraballo, Juan A Flores, Beatriz Galan-Rodriguez, Emilio Fernandez-Espejo   +4 more
doaj   +1 more source

Antisera specific for D2 dopamine receptors [PDF]

Biochemical Journal, 1993
Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine ...
Andrew J. Doherty, Philip G. Strange, Paul L. Chazot   +2 more
openaire   +3 more sources

Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine [PDF]

, 2002
The aim of this investigation was to compare the degree of striatal dopamine-(D2) receptor blockade by two atypical antipsychotic drugs, risperidone and olanzapine.
Arndt J, B. Rossmüller, Dresel S, Duncan G E, E. M. Meisenzahl, G. J. E. Schmitt, Gerlach J, H.-j. Möller, K. Hahn, K. Tatsch, Kapur S, Kerwin R W, Marder S R, Meltzer H Y, Remington G, Richelson E, S. Dresel, T. Frodl, U. W. Preuss   +18 more
core   +1 more source