Results 31 to 40 of about 121,521 (304)
Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors
eLife, 2017 The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely characterized.
Brooks G Robinson +5 more
doaj +1 more source
Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
Nature Communications, 2020 The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Most clinically approved and investigational drugs that target this receptor are known to be subfamily-selective for all
L. Fan +7 more
semanticscholar +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Antipsychotic Induced Dopamine Receptor Supersensitivity and It’s Clinical Implications
Jurnal Psikiatri Surabaya, 2022 Background : Schizophrenia is a serious mental disorder that requires multi-modal and continuous treatment, mainly with antipsychotic. Along with the increasing life expectancy of schizophrenic patients, various problems due to prolonged blocking of ...
Riko Lazuardi, Khairina Rina, Dianasari
doaj +1 more source
Frontiers in Neurology, 2012 Purpose: To assess clinical efficacy of deep brain stimulation of the pallidum in Myoclonus-Dystonia patients, and to compare pre- and postoperative striatal dopamine D2 receptor availability.Methods: Clinical parameters were scored using validated ...
Richard J. Beukers +5 more
doaj +1 more source
PharmGKB summary: dopamine receptor D2.
Pharmacogenetics & Genomics, 2011 Evolutionary Systems Biology, Artificial Intelligence Center, SRI International, Menlo Park, Departments of Genetics and Bioengineering, Stanford University, Stanford, California, USA Correspondence to Teri E.
H. Mi +6 more
semanticscholar +1 more source
Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium
eLife, 2015 D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood.
Stephanie C Gantz +6 more
doaj +1 more source
Towards the convergent therapeutic potential of GPCRs in autism spectrum disorders [PDF]
arXiv, 2022 Changes in genetic and/or environmental factors to developing neural circuits and subsequent synaptic functions are known to be a causative underlying the varied socio-emotional behavioural patterns associated with autism spectrum disorders (ASD). Seven transmembrane G protein-coupled receptors (GPCRs) comprising the largest family of cell-surface ...
arxiv
Scaffold-constrained molecular generation [PDF]
, 2020 One of the major applications of generative models for drug Discovery targets the lead-optimization phase. During the optimization of a lead series, it is common to have scaffold constraints imposed on the structure of the molecules designed. Without enforcing such constraints, the probability of generating molecules with the required scaffold is ...
arxiv +1 more source
Interaction of Arylpiperazines with the Dopamine Receptor D2 Binding Site
Arzneimittelforschung, 2005 Summary The docking of several 1-benzyl-4-arylpiperazines to the dopamine receptor (DAR) D2 was examined. The results demonstrated that the interaction of protonated N1 of the piperazine ring with Asp 86 (III.32) and edge-to-face interactions of the ...
V. Šukalović +5 more
semanticscholar +1 more source