Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence. [PDF]
, 2015 BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions.
Ballard, Michael E +7 more
core +3 more sources
Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
Cell Reports, 2015 Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson’s disease (PD) and psychiatric disorders.
Stephanie C. Gantz +4 more
doaj +1 more source
Structure of a D2 dopamine receptor-G protein complex in a lipid membrane
Nature, 2020 The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease 1 and antipsychotic drugs 2 . DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine 3 , leading to stimulation of G ...
Jie Yin +8 more
semanticscholar +1 more source
Angewandte Chemie, EarlyView.Al3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Shi‐Hua Chen +3 more
wiley +2 more sources
Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors
eLife, 2017 The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely characterized.
Brooks G Robinson +5 more
doaj +1 more source
Dopamine Activation Preserves Visual Motion Perception Despite Noise Interference of Human V5/MT [PDF]
, 2016 Copyright © 2016 Yousif et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any ...
Abou-El-Ela Bourquin, Bilal +5 more
core +3 more sources
Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
Nature Communications, 2020 The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Most clinically approved and investigational drugs that target this receptor are known to be subfamily-selective for all
L. Fan +7 more
semanticscholar +1 more source
Antipsychotic Induced Dopamine Receptor Supersensitivity and It’s Clinical Implications
Jurnal Psikiatri Surabaya, 2022 Background : Schizophrenia is a serious mental disorder that requires multi-modal and continuous treatment, mainly with antipsychotic. Along with the increasing life expectancy of schizophrenic patients, various problems due to prolonged blocking of ...
Riko Lazuardi, Khairina Rina, Dianasari
doaj +1 more source
Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants [PDF]
, 2014 Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine.
Belelli, D +8 more
core +1 more source
Molecular dynamics of dopamine at the D2 receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 A three-dimensional model of the dopamine D2 receptor, assumed to be a target of antipsychotic drug action, was constructed from its amino acid sequence. The model was based on structural similarities within the super-family of guanine nucleotide-binding regulatory (G) protein-coupled neuroreceptors and has seven alpha-helical transmembrane segments ...
Ingebright Sylte +2 more
openaire +3 more sources