Results 41 to 50 of about 121,521 (304)

Analysis of training and seed bias in small molecules generated with a conditional graph-based variational autoencoder -- Insights for practical AI-driven molecule generation [PDF]

arXiv, 2021
The application of deep learning to generative molecule design has shown early promise for accelerating lead series development. However, questions remain concerning how factors like training, dataset, and seed bias impact the technology's utility to medicine and computational chemists.
arxiv  

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Colocalization of Mating-Induced Fos and D2-Like Dopamine Receptors in the Medial Preoptic Area: Influence of Sexual Experience

Frontiers in Behavioral Neuroscience, 2016
Dopamine in the medial preoptic area (mPOA) stimulates sexual activity in males. This is evidenced by microdialysis and microinjection experiments revealing that dopamine receptor antagonists in the mPOA inhibit sexual activity, whereas agonists ...
Victoria L Nutsch, Ryan G Will, Christopher L Robison, Julia R Martz, Daniel J Tobiansky, Juan M. Dominguez, Juan M. Dominguez   +6 more
doaj   +1 more source

Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]

World Journal of Research and Review (WJRR) ISSN:2455-3956, Volume-4, Issue-5, May 2017 Pages 26-30, 2020
Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv  

In-Pocket 3D Graphs Enhance Ligand-Target Compatibility in Generative Small-Molecule Creation [PDF]

arXiv, 2022
Proteins in complex with small molecule ligands represent the core of structure-based drug discovery. However, three-dimensional representations are absent from most deep-learning-based generative models. We here present a graph-based generative modeling technology that encodes explicit 3D protein-ligand contacts within a relational graph architecture.
arxiv  

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Synaptotagmin-1 is a Ca2+ sensor for somatodendritic dopamine release

Cell Reports, 2023
Summary: Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads to D2 receptor-induced modulation of dopamine neurons on the timescale of ...
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser   +5 more
doaj  

Dopamine Receptor

Definitions, 2020
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
Raymond Turco
semanticscholar   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

npj Schizophrenia, 2017
Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes.
Zachary Freyberg, Michael J. McCarthy
doaj   +1 more source