Results 61 to 70 of about 48,073 (302)

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source

Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson’s disease

Brain Research Bulletin, 2022
Beta band (12–30 Hz) hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson’s disease (PD) pathophysiology. Abnormal beta band oscillations are found in the pedunculopontine nucleus (PPN) and primary
Xuenan Wang, Min Li, Jinlu Xie, Dadian Chen, Xiwen Geng, Shuang Sun, Bo Liu, Min Wang   +7 more
doaj  

Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates

European Journal of Organic Chemistry, EarlyView.
This work introduces an efficient and gram‐scale microwave‐assisted (3+2) cycloaddition of nitrones with fluorinated allenylphosphonates, yielding diverse 4‐phosphinyl‐pyrrolidin‐3‐ones with exclusive 4,5‐trans diastereoselectivity in moderate to good yields.
Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean‐François Poisson, Tahar Ayad, Benjamin Darses   +6 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors

The Scientific World Journal, 2007
The ability of G protein coupled receptors to heterooligomerize and create novel signaling complexes has demonstrated the tremendous potential of these receptors to access diverse signaling cascades, as well as to modulate the nature of the transduced ...
Susan R. George, Brian F. O'Dowd
doaj   +1 more source

Dichotomous Dopaminergic Control of Ventral Pallidum Neurons

Frontiers in Cellular Neuroscience, 2018
The ventral pallidum (VP) is crucially involved in reward processing. Dopaminergic afferents reach the VP from the ventral tegmental area (VTA). Recent in vivo studies suggest dopamine application increase the firing in the VP.
Martin Clark, Enrico Bracci
doaj   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

The regulation of D2 dopamine receptor expression [PDF]

Molecular Psychiatry, 1998
The question of whether or not there is a polymorphism in or near DRD2 which is associated with receptor density remains unanswered. Both clinical and animal data demonstrate that D 2 dopamine receptor density is highly variable among individuals; differences of more than 100% are not uncommon. Among inbred mouse strains and F 2 intercrosses produced
openaire   +2 more sources

Restless Legs Syndrome and Impulsive Decision‐Making: Impact of Symptom Severity, Chronotype and Interoception

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Restless Legs Syndrome (RLS) is a neurological disorder reported to be associated with impulsivity and impairments in interoception and emotional regulation. However, limited research has explored the combined influence of RLS severity, psychological factors, and chronotype on impulsive decision‐making and risk‐taking behavior in ...
Giacomo Carollo, Riccardo Quinci, Gloria Pompea Mingolla, Angela Sandri, Michele Tinazzi, Elena Antelmi   +5 more
wiley   +1 more source