Results 81 to 90 of about 48,073 (302)

Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman, Mikkel C. Vinding, Panagiota Tsitsi, Per Svenningsson, Josefine Waldthaler, Daniel Lundqvist   +5 more
wiley   +1 more source

Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach

Movement Disorders, EarlyView.
ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan, Shichun Peng, Phoebe G. Spetsieris, David Eidelberg, Yilong Ma   +4 more
wiley   +1 more source

Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5. [PDF]

Neoplasia, 2023
Jeon HM, Oh YT, Shin YJ, Chang N, Kim D, Woo D, Yeup Y, Joo KM, Jo H, Yang H, Lee JK, Kang W, Sa J, Lee WJ, Hale J, Lathia JD, Purow B, Park MJ, Park JB, Nam DH, Lee J.   +20 more
europepmc   +1 more source

Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system [PDF]

, 1989
Eric K. Richfield, John B. Penney, A. Byron Young   +2 more
openalex   +1 more source

Disease‐Modifying Trials in Treated Parkinson's Disease: “Stable Treated” Does Not Equate with Biological Stability

Movement Disorders, EarlyView.
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian, A. Jon Stoessl, Anthony E. Lang   +2 more
wiley   +1 more source

A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis. [PDF]

Braz J Psychiatry, 2023
Marques JH, Talib LL, Hortêncio L, Andrade JC, Alves TM, Serpa MH, Yamamoto GL, van de Bilt MT, Rössler W, Gattaz WF, Loch AA.   +10 more
europepmc   +1 more source

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. [PDF]

, 1988
M.G. Lacey, Nicola Biagio Mercuri, R A North   +2 more
openalex   +1 more source

A brain imaging study of dopamine receptor D₂ availability in cannabis dependent users after recovery from cannabis-induced psychosis. [PDF]

Front Psychiatry, 2023
Weinstein AM.
europepmc   +1 more source

Positive Effects of Caffeine Therapy in a Girl with PDE2A‐Related Paroxysmal Dyskinesia

Movement Disorders Clinical Practice, EarlyView.
Katerina Bernardi, Moritz Thiel, Anne Koy   +2 more
wiley   +1 more source

Tremor Asymmetry and the Development of Bilateral Phase‐Specific Deep Brain Stimulation for Postural Tremor

Movement Disorders, EarlyView.
Abstract Background Tremor phase‐locked deep brain stimulation (DBS) has been shown to modulate symptom severity in postural tremor, including essential and dystonic tremor, with less energy than existing systems. Previous studies focused on unilateral stimulation; it remains unknown how tremor asymmetry interacts with stimulation in the context of ...
Shenghong He, Alceste Deli, Timothy O. West, Fernando R. Plazas, Alek Pogosyan, Christoph Wiest, Laura Wehmeyer, Fahd Baig, Francesca Morgante, Pablo Andrade, Michael G. Hart, James J. FitzGerald, Veerle Visser‐Vandewalle, Erlick A. Pereira, Alexander L. Green, Huiling Tan, Hayriye Cagnan   +16 more
wiley   +1 more source