Results 81 to 90 of about 169,368 (383)

Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [11C]-(+)-PHNO

Psychopharmacology, 2016
Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive ...
R. Girgis, M. Slifstein, D. D’Souza, Yih Lee, A. Periclou, P. Ghahramani, I. Laszlovszky, S. Durgam, N. Adham, N. Nabulsi, Yiyun Huang, R. Carson, B. Kiss, M. Kapás, A. Abi-Dargham, A. Rakhit   +15 more
semanticscholar   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum

Journal of Pharmacological Sciences, 2012
Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain.
Naohito Tokunaga, Mohammed Emamussalehin Choudhury, Noriko Nishikawa, Masahiro Nagai, Tomoaki Tujii, Hirotaka Iwaki, Mika Kaneta, Masahiro Nomoto   +7 more
doaj   +1 more source

Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens

Molecular Brain, 2022
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune system.
Daisuke Sato, Yusuke Hamada, Michiko Narita, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Kenichi Tanaka, Sara Yoshida, Hideki Tamura, Akihiro Yamanaka, Emiko Senba, Naoko Kuzumaki, Minoru Narita   +12 more
doaj   +1 more source

Antipsychotic Drugs Influence Dopamine Neuron Terminals via Action on D2-receptors and Vesicles [PDF]

, 2013
Undergraduate Denman Research Forum - 2nd PlaceDopamine D2 antagonist antipsychotic drugs share the effects of increasing dopamine synthesis, dopamine neuron firing rate, and dopamine and DOPAC levels. These antagonists all raise extracellular dopamine
Klausing, Alex
core  

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Modulation of mechanosensation by endogenous dopaminergic signaling in the lateral parabrachial nucleus in mice

PAIN Reports
. Introduction:. The lateral parabrachial nucleus (LPBN), a crucial hub for integrating and modulating diverse sensory information, is known to express both D1 and D2 dopamine receptors and receive dopaminergic inputs.
Ho Koo, Jigong Wang, Ramesh Pariyar, Regan M. Hammond, Jun-Ho La   +4 more
doaj   +1 more source

Identifying Genetic Variants in Adolescents With Oppositional Defiant Disorders and/or Conduct Disorders: A Brief Report [PDF]

, 2016
PROBLEM To add to diversity in our state biobank, we explored the feasibility of collecting genetic material from adolescents with oppositional defiant disorder (ODD) and/or conduct disorder (CD) and their family members.
Carpenter, Janet S., Oruche, Ukamaka M., Renbarger, Jamie, Ross, Sydney E.   +3 more
core   +1 more source

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

Molecular Pharmacology, 2014
A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay.
R. Free, L. Chun, Amy E. Moritz, Brittney N. Miller, T. Doyle, Jennie L. Conroy, Adrian Padron, Julie A. Meade, Jingbo Xiao, Xin Hu, Andrés E Dulcey, Yang Han, L. Duan, S. Titus, Melanie Bryant-Genevier, E. Barnaeva, M. Ferrer, J. Javitch, T. Beuming, Lei Shi, Noel Southall, J. Marugan, D. Sibley   +22 more
semanticscholar   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source