Results 161 to 170 of about 265,775 (287)

Development and Characterization of Novel Selective, Non-Basic Dopamine D2 Receptor Antagonists for the Treatment of Schizophrenia [PDF]

, 2023
Piotr Stępnicki, Sylwia Wośko, Agata Bartyzel, Agata Zięba, Damian Bartuzi, Klaudia Szałaj, Tomasz M. Wróbel, Emilia Fornal, Jens Carlsson, Ewa Kędzierska, Ewa Poleszak, Marián Castro, Agnieszka A. Kaczor   +12 more
openalex   +1 more source

A 3D Porous MXene/PNIPAAm Hydrogel Composite with Advanced Degradation Stability and Control of Electronic Properties in Air

Advanced Science, EarlyView.
This paper reports a fundamental study of the mutual benefits of the components in an MXene/PNIPAAm hydrogel composite with regard to enhanced degradation stability and tailorable electronic properties. The presented work focuses on the investigation of the fundamental material properties and ways for their modification.
Sitao Wang, Chen Jiao, Gerald Gerlach, Julia Körner   +3 more
wiley   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Abnormally high expression of D1-like dopamine receptors on lupus CD4⁺ T cells promotes Tfh cell differentiation. [PDF]

Lupus Sci Med, 2023
Wu F, Xiang Z, He Z, Yi P, Yang M, Wu H, Hu M.   +6 more
europepmc   +1 more source

Differences in the effects of chronic treatments with aripiprazole on dopamine D2 receptors between in the rat striatum and pituitary.

, 1996
Mayumi Seto, Atsuko Inoue, Tetsuro Kikuchi, Seiji Morita, Yoshihiro Nakata   +4 more
openalex   +1 more source

Burst-Timing-Dependent Plasticity of NMDA Receptor-Mediated Transmission in Midbrain Dopamine Neurons [PDF]

, 2009
Mark T. Harnett, Brian E. Bernier, Kee-Chan Ahn, Hitoshi Morikawa   +3 more
openalex   +1 more source

Mussel‐Bioinspired Edible Ca2+‐Crosslinked Alginate Hydrogel Electrodes for Glucose Gastrointestinal Monitoring

Advanced Science, EarlyView.
A fully edible soft electrode is engineered from Ca2⁺‐crosslinked alginate integrated with polydopamine, silver nanoparticles, and food‐grade glucose oxidase. The hybrid hydrogel combines ionic and electronic conduction, enabling efficient glucose‐to‐H2O2 conversion and catalytic reduction in simulated intestinal fluid.
Verdiana Marchianò, Claudio Pellegrini, Angelo Tricase, Eleonora Macchia, Andrea Brattelli, Luigi Gentile, Patrizia Nadia Hanieh, Noemi Fiaschini, Antonio Rinaldi, Luisa Torsi, Paolo Bollella   +10 more
wiley   +1 more source

Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others. [PDF]

Nat Commun, 2023
Mikus N, Eisenegger C, Mathys C, Clark L, Müller U, Robbins TW, Lamm C, Naef M.   +7 more
europepmc   +1 more source

Facilitation of fear extinction by novelty depends on dopamine acting on D1-subtype dopamine receptors in hippocampus [PDF]

, 2015
Jefferson Menezes, Niége Alves, Sidnei Borges, Rafael Roehrs, Jociane de Carvalho Myskiw, Cristiane Regina Guerino Furini, Iván Izquierdo, Pâmela Billig Mello‐Carpes   +7 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source