Results 151 to 160 of about 240,256 (373)
ChemMedChem, Accepted Article.We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi +18 more
wiley +1 more source
Manganese Neurotoxicity and Familial Disorders of Manganese Transport
Annals of the Child Neurology Society, EarlyView.ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley +1 more source
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source
First visualization of dopaminergic neurons with a monoclonal antibody to dopamine: a light and electron microscopic study. [PDF]
, 1987 Chantal Decavel +3 more
openalex +1 more source
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
The dopaminergic innervation of the supraoptic and paraventricular nucleus. A light and electron microscopical study [PDF]
, 1984 Ruud M. Buijs +3 more
openalex +1 more source
European Eating Disorders Review, EarlyView.ABSTRACT Objective Former studies indicated worse outcome for individuals with food addiction (FA) when participating in weight loss programs. Yet, the results may have been influenced by comorbid eating disorders and insufficient consideration of psychological aspects associated with FA.
Magdalena Pape +6 more
wiley +1 more source
Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex [PDF]
, 1987 Andries Kalsbeek +5 more
openalex +1 more source
Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source