Results 161 to 170 of about 116,827 (301)

Cognition in menopausal women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cognitive health in postmenopausal women is significantly affected by hormonal shifts, especially the drop in estrogen levels. This review explores the intricate relationship between menopause and cognitive functions across six domains: perception, attention, memory, language, executive functioning, and motor skills.
Suvarna Khadilkar, Jharna Mahajan (Bhanushali), Anuradha P. Mahto, Satish Khadilkar   +3 more
wiley   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Formulation‐Dependent Cytotoxic Effects of Commercial and Analytical‐Grade Mancozeb in C6 Glial Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mancozeb (MZ) is a widely used dithiocarbamate fungicide composed of manganese (Mn) and zinc (Zn) complexes. Increasing concern has been raised regarding its occupational and human health relevance, particularly due to its neurotoxic potential associated with Mn‐related cellular dysfunction.
Lavínia Lazzarotti, Felipe Vanz, Karina Giacomini Varela, Viviane Glaser, Diego de Carvalho, Aline Pertile Remor   +5 more
wiley   +1 more source

TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson's disease. [PDF]

Cell Death Dis
Ahumada-Montalva P, Muñoz-Carvajal F, Bórquez-Macaya S, Arévalo-Ramírez N, Cisternas-Olmedo M, Jerez C, Urbina-Muñoz V, Gomez W, Urrutia PJ, Hirsch EC, Ahumada M, Barrias P, Muñoz-Yañez C, Herrera-Vásquez A, Arriagada G, Woehlbier U, Calegaro-Nassif M, Sanhueza M, Vidal RL, Rojas-Rivera D.   +19 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Reward processing in children with affective dysregulation

JCPP Advances, EarlyView.
Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner, Francisca Giller, Nathalie Holz, Anna Kaiser, Christine Igel, Sarah Hohmann, Manfred Döpfner, Veit Roessner, Christian Beste, Tobias Banaschewski, Daniel Brandeis, on behalf ofthe ADOPT Consortium   +11 more
wiley   +1 more source

Distinct radial glia subtypes regulate midbrain dopaminergic neuron development. [PDF]

Nat Neurosci
Ásgrímsdóttir ES, Bassini LF, Sun T, Puigsasllosas Pastor C, di Val Cervo PR, Gyllborg D, Lee K, Grigsby CL, Jude B, Abaurre C, Islam S, Lönnerberg P, Villaescusa C, Saltó C, Barker RA, Linnarsson S, Castelo-Branco G, La Manno G, Toledo EM, Arenas E.   +19 more
europepmc   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

GABAergic Neuron Activation in the RMTg-VTA Pathway Modulates Dopaminergic Neuron Excitability and Social Stress Susceptibility in Male Mice. [PDF]

CNS Neurosci Ther
Ma GY, Zhuang JZ, Li SF, Zhang YE, Zhang D, Zhao J, Peng Z, Yang L, Cao Z, Xie X, Jiang R, Sun H.   +11 more
europepmc   +1 more source

A multimodal mutual information‐guided feature selection framework for predicting rehabilitation response in Parkinson's disease with postural instability and gait disorder

Journal of Intelligent Medicine, EarlyView.
A mutual information–guided sequential forward selection framework applied to multimodal baseline data identified key EEG and MRI features, which showed robust predictive performance across multiple machine learning models. Abstract Postural instability and gait disorder (PIGD) subtype of Parkinson's disease (PD) is marked by heterogeneous motor and ...
Yu Shi, Hongbo Zhao, Deyu Wang, Jun Pang, Hanna Lu, Xiaodong Zhu, Lin Meng   +6 more
wiley   +1 more source