Results 81 to 90 of about 835,318 (379)
Advanced Healthcare Materials, EarlyView.Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie +5 more
wiley +1 more source
Unraveling schizophrenia replicable functional connectivity disruption patterns across sites
Human Brain Mapping, Volume 44, Issue 1, Page 156-169, January 2023., 2023 This study reported that ComBat harmonization was most robust in detecting aberrant connectivity while controlling for the false discoveries for schizophrenia. Besides, the identified three subnet‐specific composite functional connectivity measures might be considered replicable neuroimaging markers for schizophrenia.
Xiaotong Du +12 more
wiley +1 more source
Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons
Science, 2015 An alternative way of making GABA Midbrain dopaminergic neurons release both the inhibitory neurotransmitter GABA and dopamine. In the central nervous system, GABA synthesis is usually mediated by two glutamate decarboxylases (GAD65 and GAD67). Kim et al.
Jae-Ick Kim +7 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. [PDF]
PLoS ONE, 2009 BACKGROUND:Human embryonic stem cells (hESCs) may provide an invaluable resource for regenerative medicine. To move hESCs towards the clinic it is important that cells with therapeutic potential be reproducibly generated under completely defined ...
Andrzej Swistowski +5 more
doaj +1 more source
Lab on a Chip, 2015 A hallmark of Parkinson's disease is the progressive loss of nigrostriatal dopaminergic neurons. We derived human neuroepithelial cells from induced pluripotent stem cells and successfully differentiated them into dopaminergic neurons within phase-guided,
E. L. Moreno +8 more
semanticscholar +1 more source
Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease
Advanced Therapeutics, EarlyView.An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang +13 more
wiley +1 more source
Altered Brain‐Behavior Association During Resting State is a Potential Psychosis Risk Marker
Advanced Science, EarlyView.The study detects a potential multimodal biomarker that can be promising for identifying early markers of psychosis. It shows a consistent brain‐behavior association between a circuit of interconnected regions and executive function in neurotypical controls and individuals at various stages of psychosis.
Leonardo Fazio +22 more
wiley +1 more source
The Role of Dopaminergic VTA Neurons in General Anesthesia. [PDF]
PLoS ONE, 2015 Recent studies have demonstrated that the central dopaminergic system is implicated in the mechanism underlying general anesthesia. Here, we investigated whether dopaminergic ventral tegmental area (VTA) neurons participate in general anesthesia ...
Xuelong Zhou +6 more
doaj +1 more source
Cells, 2022 Pregabalin is widely used as a treatment for multiple neurological disorders; however, it has been reported to have the potential for misuse. Due to a lack of safety studies in pregnancy, pregabalin is considered the last treatment option for various ...
Walaa F. Alsanie +15 more
doaj +1 more source