Results 91 to 100 of about 3,618,545 (328)

A Mathematical Model of Flavescence Dor\'ee Epidemiology

, 2014
Flavescence dor\'ee (FD) is a disease of grapevine transmitted by an insect vector, $Scaphoideus$ $titanus$ Ball. At present, no prophylaxis exists, so mandatory control procedures (e.g.
Alma, Alberto, Lessio, Federico, Paparella, Francesco, Portaluri, Alessandro   +3 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Evaluation of anesthesiology residents in the diagnosis and control of malignant hyperthermia: comparison of three scenarios of realistic simulation ‒ a cross-sectional controlled study

Brazilian Journal of Anesthesiology
Introduction: Simulation-based training is particularly beneficial for rare and life-threatening diseases such as Malignant Hyperthermia (MH). In addition, cognitive aids, including flowcharts and checklists, can be used as guidance in crisis, reducing ...
Mariana F.L. Neville, Victor Guimarães de Almeida, Pamela Vieira Andrade, Joilson Moura Santos, Masashi Munechika, David Ferez, Mary dos Santos Silva, Leonardo Ayres Canga, Ana Cristina Tripoloni, Thierry Girard, Helga Cristina Almeida da Silva   +10 more
doaj   +1 more source

Translation and transcultural adaptation of Pain Quality Assessment Scale (PQAS) to brazilian version

Brazilian Journal of Anesthesiology, 2016
Introduction: Most cancer patients are treated with chemotherapy, and peripheral neuropathy is a serious and common clinical problem affecting patients undergoing cancer treatment.
Anamada Barros Carvalho, João Batista Santos Garcia, Thayanne Kelly Muniz Silva, João Victor Fonseca Ribeiro   +3 more
doaj   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Postoperative persistent chronic pain: what do we know about prevention, risk factors, and treatment

Brazilian Journal of Anesthesiology, 2016
Background and objectives: Postoperative persistent chronic pain (POCP) is a serious health problem, disabling, undermining the quality of life of affected patients.
Durval Campos Kraychete, Rioko Kimiko Sakata, Leticia de Oliveira Carvalho Lannes, Igor Dórea Bandeira, Eduardo Jun Sadatsune   +4 more
doaj   +1 more source

Factores que influenciam a percepção da dor pós-operatória em indivíduos submetidos a cirurgia cardíaca [PDF]

, 2003
Procedeu-se à investigação de factores que influenciam a percepção da dor pós-operatória em doentes submetidos a cirurgia cardíaca, usando uma amostra de 93 indivíduos sujeitos a bypass coronário no ano de 2002, no hospital de Santa Marta, 78,5% do ...
Nave Leal, Elisabete
core  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Ultrasound-guided selective nerve blocks for trigger finger surgeries to maintain flexion/extension of fingers – Case series

Brazilian Journal of Anesthesiology, 2019
Background: A patient's ability to move his/her fingers during hand surgery may be helpful to surgeons because it allows the effectiveness of the intervention evaluation and prediction of hand function in the postoperative period.
Fernanda Moreira Gomes Mehlmann, Leonardo Henrique Cunha Ferraro, Paulo César Castello Branco de Sousa, Graziella Prianti Cunha, Esthael Cristina Querido Avelar Bergamaschi, Alexandre Takeda   +5 more
doaj   +1 more source