Results 61 to 70 of about 2,975,612 (292)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Postoperative persistent chronic pain: what do we know about prevention, risk factors, and treatment
Brazilian Journal of Anesthesiology, 2016 Background and objectives: Postoperative persistent chronic pain (POCP) is a serious health problem, disabling, undermining the quality of life of affected patients.
Durval Campos Kraychete +4 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Brazilian Journal of AnesthesiologyIntroduction: Simulation-based training is particularly beneficial for rare and life-threatening diseases such as Malignant Hyperthermia (MH). In addition, cognitive aids, including flowcharts and checklists, can be used as guidance in crisis, reducing ...
Mariana F.L. Neville +10 more
doaj +1 more source
Peripheral nerve block and rebound pain: literature review
Brazilian Journal of Anesthesiology, 2019 Background and objectives: To investigate, describe, and assess the phenomenon of “rebound pain” as a clinically relevant problem in anesthetic practice. Content: The phenomenon of “rebound pain” has been demonstrated and described as a very severe pain,
Layana Vieira Nobre +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Pain management in children with erythromelalgia: case report
Brazilian Journal of Anesthesiology, 2018 Erythromelalgia is a neuropathic pain syndrome due to an autosomal dominant gene, characterized by erythema, increased skin temperature and burning pain in hands and feet, whose treatment is often unsatisfactory.
Estela Irene Bortoli +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Neurociência da dor: exercícios para dor crônica
Estudios y Perspectivas Revista Científica y AcadémicaIntrodução: Na dor crônica, o sistema nervoso muitas vezes se torna hiperativo, gerando dor persistente e debilitante. Compreender os mecanismos neurobiológicos por trás da dor crônica é crucial para desenvolver tratamentos mais eficazes. Objetivo: Compreender a importância da neurociência relacionando para os exercícios para dor crônica.
LUIZ FELIPE CHAVES CARVALHO +1 more
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source