Results 1 to 10 of about 653,638 (208)

The Role of Dorsal Raphe Nucleus Neuropeptides in Reward and Aversion [PDF]

Frontiers in Behavioral Neuroscience
The dorsal raphe nucleus is a critical node for affective and motivated circuits in the brain. Though typically known as a serotonergic hub, the dorsal raphe nucleus is also highly enriched in a variety of neuropeptides.
Daniel C Castro
exaly   +6 more sources

Role of the Dorsal Raphe Nucleus in Pain Processing [PDF]

Brain Sciences
The dorsal raphe nucleus (DRN) has gained attention owing to its involvement in various physiological functions, such as sleep–awake, feeding, and emotion, with its analgesic role being particularly significant.
Huijie Zhang, Lei Li, Xujie Zhang, Guanqi Ru, Weidong Zang   +4 more
doaj   +4 more sources

Dorsal raphe nucleus MC4R-GABAergic neurons regulate feeding and anxiety [PDF]

Molecular Metabolism
Objective: The melanocortin receptor 4 (MC4R) plays a key role in the CNS regulation of metabolism. In addition to its role within the hypothalamus, other brain areas, including the dorsal raphe nucleus (DRN), express MC4R. However, the identity and role
Satoshi Yamagata, Francesca Copperi, Gavin Thomas White, Jung Dae Kim, Sabrina Diano   +4 more
doaj   +2 more sources

Electrophysiological Characteristics of Dorsal Raphe Nucleus in Tail Suspension Test [PDF]

Frontiers in Behavioral Neuroscience, 2022
The dorsal raphe nucleus (DRN) is a major source of serotonin in the central nervous system, which is closely related to depression-like behaviors and is modulated by local GABAergic interneurons.
Liuchang Zhou, Liuchang Zhou, Dan Liu, Zedan Xie, Di Deng, Di Deng, Guoqi Shi, Jinlan Zhao, Shasha Bai, Lei Yang, Rong Zhang, Yafei Shi   +11 more
doaj   +2 more sources

Dorsal raphe nucleus–hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice [PDF]

Translational Neurodegeneration
Background Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, the neural circuit mechanisms underlying the AD-associated depression remain unclear.
Meiqin Chen, Chenlu Wang, Yinan Lin, Yanbing Chen, Wenting Xie, Xiaoting Huang, Fan Zhang, Congrui Fu, Kai Zhuang, Tingting Zou, Dan Can, Huifang Li, Shengxi Wu, Ceng Luo, Jie Zhang   +14 more
doaj   +2 more sources

Distribution of VGLUT3 in highly collateralized axons from the rat dorsal raphe nucleus as revealed by single-neuron reconstructions. [PDF]

PLoS ONE, 2014
This study aimed at providing the first detailed morphological description, at the single-cell level, of the rat dorsal raphe nucleus neurons, including the distribution of the VGLUT3 protein within their axons.
Dave Gagnon, Martin Parent
doaj   +1 more source

Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei

eLife, 2021
The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated.
Zhengchao Xu, Zhao Feng, Mengting Zhao, Qingtao Sun, Lei Deng, Xueyan Jia, Tao Jiang, Pan Luo, Wu Chen, Ayizuohere Tudi, Jing Yuan, Xiangning Li, Hui Gong, Qingming Luo, Anan Li   +14 more
doaj   +1 more source

Expression of Repressor Element 1 Silencing Transcription Factor (REST) in Serotonin Neurons in the Adult Male Nile Tilapia (Oreochromis niloticus)

Frontiers in Neuroanatomy, 2021
Repressor element-1 silencing transcription factor (REST) is highly expressed in the dorsal raphe where serotonin (5-hydroxytryptamine, 5-HT) neurons are located.
Tomoko Soga, Shingo Nakajima, Ishwar S. Parhar   +2 more
doaj   +1 more source

A structural connectivity atlas of limbic brainstem nuclei

Frontiers in Neuroimaging, 2023
BackgroundUnderstanding the structural connectivity of key brainstem nuclei with limbic cortical regions is essential to the development of therapeutic neuromodulation for depression, chronic pain, addiction, anxiety and movement disorders.
Simon Levinson, Simon Levinson, Michelle Miller, Ahmed Iftekhar, Monica Justo, Daniel Arriola, Wenxin Wei, Saman Hazany, Josue M. Avecillas-Chasin, Taylor P. Kuhn, Andreas Horn, Andreas Horn, Andreas Horn, Ausaf A. Bari   +13 more
doaj   +1 more source

Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons

eLife, 2020
The dorsal raphe nucleus is the predominant source of central serotonin, where neuronal activity regulates complex emotional behaviors. Action potential firing of serotonin dorsal raphe neurons is driven via α1-adrenergic receptors (α1-AR) activation ...
Stephanie C Gantz, Khaled Moussawi, Holly S Hake   +2 more
doaj   +1 more source