Results 31 to 40 of about 1,233,920 (254)

Spike filtering at the dorsal root ganglia

, 2022
This is a collection of metadata files corresponding to the figures in the PLOS Biology article "Dorsal root ganglia control nociceptive input to the central nervous system" by Hao H, Ramli R, Wang C, Liu C, Shah S, Mullen P, Lall V, Jones F, Shao J ...
Wang, Caixue, Liu, Chao, Jaffe, David B., Ramli, Rosmaliza, Shah, Shihab, Shao, Jicheng, Mullen, Pierce, Lall, Varinder, Du, Xiaona, Gamper, Nikita, Zhang, Hailin, Hao, Han, Jones, Frederick   +12 more
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Electroacupuncture downregulates P2X3 receptor expression in dorsal root ganglia of the spinal nerve-ligated rat

Molecular Pain, 2019
Electroacupuncture has been shown to effectively reduce chronic pain in patients with nerve injury. The underlying mechanisms are not well understood. Accumulated evidence suggests that purinergic P2X3 receptors (P2X3Rs) in dorsal root ganglion neurons ...
Yi Liang, Yanping Gu, Renyi Shi, Guangwen Li, Yong Chen, Li-Yen Mae Huang   +5 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia

Frontiers in Molecular Neuroscience, 2012
RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie, Fumiyasu eImai, Xuan eZhou, Richard A Lang, Yi eZheng, Yutaka eYoshida   +5 more
doaj   +1 more source

Global transcriptome analysis of rat dorsal root ganglia to identify molecular pathways involved in incisional pain

Molecular Pain, 2020
To develop non-opioid therapies for postoperative incisional pain, we must understand its underlying molecular mechanisms. In this study, we assessed global gene expression changes in dorsal root ganglia neurons in a model of incisional pain to identify ...
Phu V Tran, Malcolm E Johns, Brian McAdams, Juan E Abrahante, Donald A Simone, Ratan K Banik   +5 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Evoked hypoalgesia is accompanied by tonic pain and immune cell infiltration in the dorsal root ganglia at late stages of diabetic neuropathy in mice

Molecular Pain, 2018
Diabetic peripheral neuropathy is a major debilitating late complication of diabetes, which significantly reduces the quality of life in patients. Diabetic peripheral neuropathy is associated with a wide spectrum of sensory abnormalities, where in loss ...
Nitin Agarwal, Johanna Helmstädter, Daniel R Rojas, Kiran K Bali, Vijayan Gangadharan, Rohini Kuner   +5 more
doaj   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

The dorsal root ganglion as a target for neurorestoration in neuropathic pain

Neural Regeneration Research
Neuropathic pain is a severe and chronic condition widely found in the general population. The reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in patients.
Guillermo Estivill-Torrús, Ana Belen Martínez-Padilla, Lourdes Sánchez-Salido, Anne Baron-Van Evercooren, Beatriz García-Díaz   +4 more
doaj   +1 more source