Results 231 to 240 of about 39,387 (246)

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes. [PDF]

Annu Rev Genomics Hum Genet
Cheng P, Singh K, Reeves RH, Davoli T.
europepmc   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Transgressive expression and dosage effect of A09 chromosome genes and their homoeologous genes influence the flowering time of resynthesized allopolyploid Brassica napus. [PDF]

BMC Plant Biol
Bai Y, Zhao K, Wang B, Wu L, Xiong Z.
europepmc   +1 more source

Synaptic Vesicle Disruption in Parkinson's Disease: Dual Roles of α-Synuclein and Emerging Therapeutic Targets. [PDF]

Brain Sci
Treviño M, Guerra-Crespo M, Padilla-Godínez FJ, Ortega-Robles E, Arias-Carrión O.   +4 more
europepmc   +1 more source

Human Single-Cell RNA-Sequencing Data Supports the Hypothesis of X Chromosome Insensitivity but Is Ineffective in Testing the Dosage Compensation Model. [PDF]

Mol Biol Evol
Chen J, Chen X.
europepmc   +1 more source

Genetic evaluation of CRISPR-Cas9 off-target effects from deleterious mutations on Drosophila male single X chromosome. [PDF]

Funct Integr Genomics
Bian W, Mcquarrie DWJ, Haussmann IU, Arnold R, Soller M.   +4 more
europepmc   +1 more source

Homoeolog expression in polyploid wheat mutants shows limited transcriptional compensation. [PDF]

New Phytol
Dorussen D, Knight E, Simmonds J, Borrill P.   +3 more
europepmc   +1 more source

Contrasting behavioral and physiological effects of Gtf2i duplication and deletion in mouse models of the 7q11.23 Duplication and Williams-Beuren Syndromes

Peles D, Netser S, Ray N, Suliman T, Wagner S.   +4 more
europepmc   +1 more source

Feminization of sex-biased gene expression in a parthenogenetic stick insect suggests unresolved sexual antagonism in early development

Djordjevic J, Labédan M, Schwander T, Parker DJ.   +3 more
europepmc   +1 more source