Results 291 to 300 of about 1,171,051 (326)

Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation

Trends in Genetics, 2013
High-throughput genomic analyses have shown that many mutations, including loss-of-function (LOF) mutations, are present in diseased as well as in healthy individuals. Gene dosage effects due to deletions, duplications, and LOF mutations provide avenues to explore oligo- and multigenic inheritance. Here, we focus on several mechanisms that mediate gene
Reiner A, Veitia, Samuel, Bottani, James A, Birchler   +2 more
openaire   +2 more sources

Dosage compensation in Drosophila

Trends in Genetics, 1986
Abstract Dosage compensation in Drosophila is accomplished by a twofold transcriptional hyperactivation of the male X relative to each female X chromosome. A number of chromosomal signals and control genes have been implicated in this process.
Elizabeth Jaffe, Charles Laird
openaire   +1 more source

Two CCCH-type zinc finger domains in the Masc protein are dispensable for masculinization and dosage compensation in Bombyx mori.

Insect Biochemistry and Molecular Biology, 2019
The Masculinizer (Masc) gene encodes a novel lepidopteran-specific protein that controls both masculinization and dosage compensation in the silkworm Bombyx mori.
T. Kiuchi, Yudai Sugano, T. Shimada, S. Katsuma   +3 more
semanticscholar   +1 more source

Chromatin Mechanisms in Drosophila Dosage Compensation

2005
Dosage compensation ensures that males and females equalize the expression of the X-linked genes and therefore provides an exquisite model system to study chromosome-wide transcription regulation. In Drosophila, this is achieved by hyper-transcription of the genes on the male X chromosome.
Mikko, Taipale, Asifa, Akhtar
openaire   +2 more sources

A brief history of dosage compensation

Journal of Genetics, 2014
In 1914, H. J. Muller postulated the origin of the Y chromosome as having resulted from restricted recombination between homologous sex chromosomes in the male and the accumulation of deleterious mutations. This evolutionary process leads to dosage compensation. This article lays out a brief history of dosage compensation in genetics.
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Unwinding dosage compensation

Cell, 1993
Henikoff, S., Meneely, Philip M.
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Dosage compensation: making 1X equal 2X

Trends in Cell Biology, 2000
Animals that have XX females and XY or XO males have differing doses of X-linked genes in each sex. Overcoming this is the most immediate and vital aspect of sexual differentiation. A number of systems that accurately compensate for sex-chromosome dosage have evolved independently: silencing a single X chromosome in female mammals, downregulating both ...
openaire   +2 more sources

DOSAGE COMPENSATION IN DROSOPHILA

Annual Review of Genetics, 1994
B S, Baker, M, Gorman, I, Marín
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Dosage Compensation

2005
openaire   +2 more sources

Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription

Nature Reviews Genetics, 2012
Thomas Conrad, Asifa Akhtar
exaly