Game, Set, and Match: A Scoping Review of Matching Characteristics for Control and Intervention Groups in Adaptive Behavioral Interventions for Physical Activity or Healthy Eating Designs for Populations with Overweight and Obesity. [PDF]
Behav MedWhitney J +8 more
europepmc +1 more source
Role of X chromosome and dosage-compensation mechanisms in complex trait genetics
American Journal of Human GeneticsThe X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX on human complex traits remains debated.
Matti Pirinen, Taru Tukiainen, Yu Fu
exaly +5 more sources
X-Ray Microscopic Studies of the Drosophila Dosage Compensation Complex
Journal of Structural Biology, 2000 X-raymicroscopy is applied to detect specific proteins in whole cell nuclei of Drosophila melanogaster using immunogold labeling and silver enhancement. As a model for a small subnuclear structure the Drosophila dosage compensation protein MSL-1 was chosen.
Stefan Vogt, G Schmahl
exaly +4 more sources
Related searches:
[Research advance of dosage compensation and MSL complex].
Yi chuan = Hereditas, 2012Dosage compensation effect, which exists widely in eukaryotes with sexual reproduction, is an essential biological process that equalizes the level of gene expression between genders based on sex determination. In Drosophila, the male-specific lethal (MSL) complex mediates dosage compensation by acetylating histone H4 lysine K16 on nucleosome of some ...
Min-Qiu, Sun +4 more
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Recycling to remodel: evolution of dosage-compensation complexes
Current Opinion in Genetics & Development, 2000In diploid species where sex determination involves heteromorphic sex chromosomes, a mechanism has evolved to compensate for gene-dosage differences in sex-linked genes between the sexes. This regulatory mechanism, which is based on chromatin remodeling, is the function of complexes that include components themselves involved in other cellular ...
A, Pannuti, J C, Lucchesi
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MSL1 plays a central role in assembly of the MSL complex, essential for dosage compensation in Drosophila [PDF]
EMBO Journal, 2000 In male Drosophila, histone H4 acetylated at Lys16 is enriched on the X chromosome, and most X-linked genes are transcribed at a higher rate than in females (thus achieving dosage compensation). Five proteins, collectively called the MSLs, are required for dosage compensation and male viability.
Maxwell Scott
exaly +3 more sources
A Functional Dosage Compensation Complex Required for Male Killing in Drosophila
Science, 2005Bacteria that selectively kill males (“male-killers”) were first characterized more than 50 years ago in Drosophila and have proved to be common in insects. However, the mechanism by which sex specificity of virulence is achieved has remained unknown. We tested the ability of
Zoe, Veneti +4 more
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Sex-Specific Assembly of a Dosage Compensation Complex on the Nematode X Chromosome
Science, 1996In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans
P T, Chuang, J D, Lieb, B J, Meyer
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Dosage compensation in Drosophila and the ‘complex’ world of transcriptional regulation
BioEssays, 1996AbstractThe purpose of this review is to draw attention to the mechanism of dosage compensation in Drosophila as a model for the study of the regulation of gene activity through the modulation of transcription. Dosage compensation resembles some mechanisms of transcriptional regulation, found in widely divergent organisms, that do not play a role in ...
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Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1
Nature Structural & Molecular Biology, 2011The male-specific lethal (MSL) complex is required for dosage compensation in Drosophila melanogaster, and analogous complexes exist in mammals. We report structures of binary complexes of mammalian MSL3 and the histone acetyltransferase (HAT) MOF with consecutive segments of MSL1.
Jan Kadlec +6 more
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