BMC Public Health, 2023 Background The dose‒response relationship-based relative risk (RR) of smoking exposure could better predict the risk of lung cancer than the dichotomous RR.
Feiling Ai +3 more
doaj +1 more source
Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy. [PDF]
, 2002 In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g x kg(-1) x wk(-1) or to a control group receiving epoetin alfa at an initial dose of 150 U x kg(-1) three times weekly.
Armstrong, S +10 more
core +2 more sources
Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors [PDF]
, 1995 We constructed chimeras of the rat beta 2 and beta 4 neuronal nicotinic subunits to locate the regions that contribute to differences between the acetylcholine (ACh) dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 receptors ...
Cohen, B. N. +5 more
core +2 more sources
Model Selection versus Model Averaging in Dose Finding Studies [PDF]
, 2015 Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn +3 more
core +2 more sources
World Allergy Organization Journal, 2020 Background: Generally, oral immunotherapy (OIT) aims for daily administration. Recently, the efficacy of treatment with OIT at a low dose has been reported.
Kiyotake Ogura +20 more
doaj +1 more source
Dose response relationship in anti-stress gene regulatory networks. [PDF]
PLoS Computational Biology, 2007 To maintain a stable intracellular environment, cells utilize complex and specialized defense systems against a variety of external perturbations, such as electrophilic stress, heat shock, and hypoxia, etc.
Qiang Zhang, Melvin E Andersen
doaj +1 more source
A Poisson Regression Model for Female Radium Dial Workers [PDF]
, 2012 A Poisson regression model with interaction terms was applied to study the dose response relationship for radium-induced skeletal cancers. The model showed that the expected frequency count of bone tumors depended not only on the logarithmic dose and the
Lee, Tze-San
core +2 more sources
Evaluation of mutagenicity of zinc oxide nanoparticles by Pig-a mutation assay in vivo
Shanghai yufang yixue, 2022 ObjectiveThe genotoxicity of zinc oxide nanoparticles （ZnO NPs） in rats was determined by Pig⁃a mutation assay in vivo.MethodsCombined with 28-day oral toxicity test， male SD rats were given ZnO NPs by oral administration for 28 days， at doses of 0， 14 ...
CHENG Xueqing +4 more
doaj +1 more source
PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response. [PDF]
, 2016 PurposeThe purpose of our study is to determine if there is a relationship between dose deposition measured by PET/MRI and individual lesion response to yttrium-90 ((90)Y) microsphere radioembolization.Materials and methods26 patients undergoing lobar ...
Fowler, Kathryn J +7 more
core +2 more sources
Dose-response relationship for breast cancer induction at radiotherapy dose
Radiation Oncology, 2011 Purpose Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer.
Gruber Günther +5 more
doaj +1 more source